Category: 163165-92-2

Synthesis of chiral aryloxazoline hydroaluminum and its asymmetric reduction for ketones was written by Wu, Hai-Chen; Xu, Dong-Cheng; Hua, Wen-Ting. And the article was included in Huaxue Xuebao on August 31,2001.Reference of 163165-92-2 The following contents are mentioned in the article:

Title compounds I (R = (CH3)2CHCH2, (CH3)2CH, C6H5CH2) as chiral ligands, were prepared A new type of title compounds I modified lithium aluminum hydride reducing agents (DIOAL-H) were prepared, which exhibited moderate enantioselectivity in the reduction of different ketones, R2COCH3 (R2 = C6H5, 2-naphthyl, CH3(CH2)3). This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Reference of 163165-92-2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Reference of 163165-92-2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

The Synthesis of Novel Oxazolinylphosphinic Esters and Amides and Application to the Cyanosilylation of Aldehydes was written by Luo, Mei. And the article was included in Current Organic Synthesis on October 31,2015.Formula: C16H15NO2 The following contents are mentioned in the article:

A new class of modular functionalized oxazolines were synthesized using a simple, novel 1-pot method under inert moisture-free conditions. Then the oxazolines can be further elaborated to phosphine-containing oxazolines. The 1st step is to synthesize intermediates via the reaction of 2-hydroxybenzonitrile or 2-aminobenzonitrile with chiral amino alcs., subsequent reactions with phosphine chlorides, providing products in moderate yields. Product structures are fully characterized by NMR, IR, MS and x-ray analyses. These compounds are highly active catalysts for the cyanosilylation of prochiral benzaldehyde (20-96% yield). This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Formula: C16H15NO2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Formula: C16H15NO2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Enantioselective addition of diethylzinc to aromatic aldehydes with chiral 2-oxazolinyl phenol as catalysts was written by Li, Xin-sheng; Wu, Xiao-hua; Fang, Ke-ming. And the article was included in Zhejiang Shifan Daxue Xuebao, Ziran Kexueban on November 30,2005.Electric Literature of C16H15NO2 The following contents are mentioned in the article:

Chiral 2-oxazolinyl phenols were prepared and applied in the addition reaction of diethylzinc to aromatic aldehydes with moderate enantioselectivity. Ligand I was found to show the best asym. induction in the addition reaction of p-chlorobenzaldehyde to provide sec-alc. with 85% yield and 63% ee. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Electric Literature of C16H15NO2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Electric Literature of C16H15NO2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Chiral phosphoramidate compound used as chiral catalyst was written by Luo, Mei. And the patent was published on May 25,2011.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:

The invention relates to chiral phosphoramidate compound as shown in formula I, wherein R is -CH2CH(CH3)2 or -CH(CH3)2 or -CH2Ph. Title chiral phosphoramidate compound is prepared by allowing to react 2-cyanophenol with L-amino alc. in chlorobenzene solvent for 24 h under water-free and oxygen-free conditions and refluxing in the presence of anhydrous ZnCl2 as catalyst to obtain 2-[(4S)-4,5-dihydro-4-R-2-oxazolinyl]phenol intermediate, then reacting with phenylphosphonyl dichloride in toluene-triethylamine solvent under refluxing for 24 h. The inventive product can be used as chiral catalyst, showing fine catalytic activity and high enantioselectivity in asym. cyanosilylation of 2-methylbenzaldehyde. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Palladium-Catalyzed C-2 C-H Heteroarylation of Chiral Oxazolines: Diverse Synthesis of Chiral Oxazoline Ligands was written by Xi, Tuo; Mei, Yuncai; Lu, Zhan. And the article was included in Organic Letters on December 18,2015.Formula: C16H15NO2 The following contents are mentioned in the article:

A direct, efficient, and practical protocol to install a chiral oxazoline unit onto aryl/heteroaryl rings via palladium-catalyzed C-H functionalization of 2-positions of oxazolines with a variety of halides using dppe as the ligand has been developed. Various chiral oxazoline ligands could be synthesized, even in a 10-g scale process. This protocol is a good supplement to traditional methods and for diverse synthesis of chiral oxazoline ligands. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Formula: C16H15NO2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Formula: C16H15NO2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Method for synthesis of diphenylphosphinic acid was written by Luo, Mei. And the patent was published on February 15,2012.Electric Literature of C16H15NO2 The following contents are mentioned in the patent:

The title method comprises preparing 2-[(4R/S)-4,5-dihydro-4-R-2-oxazolinyl]phenol or 2-[(4R/S)-4,5-dihydro-4-R-2-oxazolinyl]aniline, reacting with diphenylphosphinyl chloride in toluene in the presence of triethylamine for 2 days, filtering, evaporating, carrying out chromatog. with petroleum ether-dichloromethane (1:9) as eluent and volatilizing to obtain diphenylphosphonic acid crystal. The yield is about 5%. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Electric Literature of C16H15NO2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Electric Literature of C16H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Transition metal oxo, sulfido and amido complexes as catalysts of nucleophilic addition reactions was written by Grubbs, Robert H.; Toste, F. Dean. And the patent was published on December 27,2002.HPLC of Formula: 163165-92-2 The following contents are mentioned in the patent:

Methods are provided for carrying out nucleophilic addition reactions using oxo, sulfido or amido complexes of transition metals as reaction catalysts. Exemplary catalysts are oxo complexes of Group 7 transition metals, with Re(V) oxo complexes, including dioxo complexes, preferred. Nucleophilic addition reactions that can be catalyzed using the present methods include silylation, hydrosilylation, hydroamination, silylmetalation, carbometalation, aldol reactions, hydro- and carbometalation initiated cyclization/polymerization, and epoxide/aziridine opening. The invention also pertains to novel transition metal complexes that have utility in catalyzing such reactions. For example, [ReO2L2]CN was prepared from ReO(AsPh3)2Cl3 and (4S)-(+)-phenyl-α-phenyloxazolin-2-oxazoline-2-acetonitrile. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2HPLC of Formula: 163165-92-2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.HPLC of Formula: 163165-92-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Chiral phosphonic acid ester and its synthesis method was written by Luo, Mei. And the patent was published on December 2,2009.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:

The invention relates to a chiral phosphonic acid ester, diphenylphosphonic acid-2-[(4S)-4,5-dihydro-4-R-2-oxazolinyl]phenol ester I, wherein R is -CH2CH(CH3)2, -CH(CH3)2, -Ph or -CH2ph. The method for synthesis of the chiral phosphonic acid ester comprises reacting 2-cyanophenol with L-amino alc. in water-free and oxygen-free condition in the presence of anhydrous ZnCl2 in chlorobenzene under reflux for 24 h to obtain intermediate, reacting with diphenylphosphinyl chloride in water-free and oxygen-free condition in toluene-triethylamine solvent under reflux for 24 h, isolating and purifying. The chiral phosphonic acid ester can react with metal organic compound to form complex, which exhibits high catalytic activity and high enantiomorphous selectivity in asym. synthesis of amygdalic acid. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Preparation of substituted alkynes by nucleophilic substitution reactions catalyzed by rhenium oxo complexes was written by Toste, F. Dean. And the patent was published on September 16,2004.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:

A method is provided for synthesizing substituted alkynes from alkyne reactants R1R2CXCCR3 [X = leaving group; R1 = H, (un)substituted C1-24 hydrocarbyl; R2 = H, (un)substituted C1-24 hydrocarbyl, functional group; R3 = H, silyl, (un)substituted C1-24 hydrocarbyl] and a nucleophile using rhenium (V) oxo complex as a catalyst. The method does not require activation of the leaving group or ionization of the nucleophilic reactant, and may be carried out in the presence of air and moisture. The invention is useful in synthesizing propargyl ethers, propargyl amines, and the like. Thus, reaction of PhCH(OH)CC(CH2)3CH3 with 3-chloropropanol in MeCN with 5 mol % (dppm)ReOCl3 gave 96% propargylic ether PhCH(OCH2CH2CH2Cl)CC(CH2)3CH3. The substitution reaction was also carried out with nitrogen and carbon nucleophiles. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Chiral phosphine compound, its synthesis method and application was written by Luo, Mei. And the patent was published on September 23,2009.Quality Control of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:

The invention provides a method for the synthesis of chiral phosphine compounds of formula I (R = iso-Bu, iso-Pr, Ph, and benzyl), which comprises allowing to react 2-cyanophenol with L-amino alc. in the presence of anhydrous Compounds of formula I were prepared via cyclization of 2-cyanophenol with L-amino alcs.; the resulting (oxazolinyl)phenols underwent condensation with phenylphosphonic dichloride to give I. The L-amino alcs. are selected from L-leucinol, L-valinol, L-Ph glycinol, and L-Ph alaninol. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Quality Control of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Quality Control of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem