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[Chemical Equation Presented] Pamamycin 621A was synthesized through a convergent route, with the THF rings constructed from Evans aldols in the presence of the chiral auxiliaries without suffering racemization or elimination. The basic amino group was introduced at a late stage through reduction of an azido group with n-Bu3SnH, which also demonstrates for the first time the great potential of this largely forgotten reduction protocol in synthesis of multifunctional substrates.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2249NO – PubChem

 

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An efficient enantioselective route to nonactin using a novel beta-inversion of an Evans syn aldol to construct the THF ring is presented. Through total synthesis, the structure for trilactone proposed in the literature is shown likely to be incorrect.

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Oxazolidine – Wikipedia,
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The present invention provides a dolastatin-10 derivative having excellent anticancer activity, a method of producing the same and anticancer drug composition containing the same as an active ingredient.

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Oxazolidine – Wikipedia,
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(Matrix presented) Electrochemical carboxylation of N-(2-bromopropionyl)-4R-phenyloxazolidin-2-one aimed at the synthesis and chiral resolution of unsymmetrical methylmalonic ester derivatives is described. The presence of the Evans’ chiral auxiliary permits an easy resolution of the mixture of the two diastereoisomers.

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Oxazolidine – Wikipedia,
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Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts

A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2245NO – PubChem

 

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Related Products of 160695-26-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.160695-26-1, Name is (R)-4-Phenyl-3-propionyloxazolidin-2-one, molecular formula is C12H13NO3. In a article,once mentioned of 160695-26-1

AHU – 377 preparation method of the midbody and intermediate and intermediate preparation method (by machine translation)

The invention relates to the field of chemical synthesis, in particular to a AHU – 377 preparation method of the midbody and intermediate and intermediate preparation method. Formula (I) indicated by the AHU – 377 intermediate preparation method, the method comprising the formula (II) compound of formula (III) compounds are shown by the substitution reaction after hydrolysis of the formula (I) through the indicated by the AHU – 377 of the intermediate, the hydrolysis reaction of the hydrogen peroxide and hydrated lithium is carried out in the presence: Another purpose of this invention is to provide a novel compound, having a structure of formula (II) as shown: In the new route of the present invention, the formula (II) compound of formula (III) shown in preparation to obtain new compounds of formula (IV) as shown in the, selectivity is very good, generated during the reaction process of a very low amount of diastereoisomers, these thimbleful diastereoisomer also only needs through simple post-treatment can be removed. (by machine translation)

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Oxazolidine – Wikipedia,
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An enantioselective convergent route to pamamycin 621A

(Figure presented) An effective approach to the total synthesis of natural antibiotic pamamycin 621A is described, in which the stereogenic centers at the C-13 and C-15 were taken from a chiral building block derived from the inexpensive d-glucolactone while all others (except the C-10) were installed via chiral auxiliary-induced asymmetric Evans/Crimmins aldol reactions. In the synthesis of the smaller/lower fragment, an antiselective Evans aldol condensation was found to occur only if a stoichiometric (rather than catalytic as reported in the literature) amount of magnesium chloride was present. A previously unknown effect of the steric bulkiness of the pyridine base employed on the stereochemical outcome of the formation of the THF ring in the presence of a chiral auxiliary was also observed. The THF rings in the larger/upper fragment were similarly synthesized with a high level of stereoselectivity from a linear precursor carrying a chiral auxiliary via intramolecular O-alkylations, most notably even under acidic conditions. The basic dimethylamino functionality at the C-15 was installed at the final stage of the whole synthesis, with those otherwise unavoidable side reactions in the conversion of the azido group effectively circumvented through using a very mild yet largely forgotten tributyltin reduction protocol.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2247NO – PubChem

 

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Synthesis of alpha-CF3-substituted carbonyl compounds with relative and absolute stereocontrol using electrophilic CF3-transfer reagents

Evans-type chiral lithium imide enolates undergo diastereoselective alpha-trifluoromethylation with a hypervalent iodine-CF3 reagent with up to 91% combined isolated yield and 97:3 dr. The resulting isolated diastereopure products can be further transformed into valuable products without racemization.

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Oxazolidine – Wikipedia,
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Application of 160695-26-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 160695-26-1, (R)-4-Phenyl-3-propionyloxazolidin-2-one, introducing its new discovery.

PROCESS FOR THE PREPARATION OF (1S,3S,7S,10R,11S,12S,16R)-7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[(1E)-1-METHYL-2-(2-METHYL-4-THIAZOLYL)ETHENYL]-17-OXA-4-AZABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE AND INTERMEDIATES THEREOF

The present invention relates to an improved process for the preparation of (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2- methyl-4-thiazolyl)ethenyl]- 17-oxa-4-azabicyclo[ 14.1.0]heptadecane-5,9-dione represented by the following structural formula I and intermediates thereof. The present invention also provides novel intermediate compounds useful for the preparation of compound of formula I and its intermediates.

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Oxazolidine – Wikipedia,
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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of (R)-4-Phenyl-3-propionyloxazolidin-2-one, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 160695-26-1, in my other articles.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of (R)-4-Phenyl-3-propionyloxazolidin-2-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 160695-26-1, Name is (R)-4-Phenyl-3-propionyloxazolidin-2-one, molecular formula is C12H13NO3

Development of a scalable process for 1-beta-methyl azetidinone: A carbapenem key intermediate

An optimized process for the stereoselective synthesis of 1-beta-methyl carbapenem key intermediate (3S,4S)-[(R)-1?-((tert-butyldimethylsilyl)oxy) ethyl]-4-[(R)-1-carboxyethyl]-2-azetidinone (1) and (3R,4R)-4-acetoxy-3-[(R)- 1?-((tert-butyldimethylsilyl)oxy)ethyl]-2-azetidinone has been developed employing commercially available chiral 4-phenyl-2-oxazolidinone. This method provides an efficient and cost-effective process with improved selectivity and higher yield.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2252NO – PubChem