Category: 150699-10-8

Inhibition of TLR1/2 dimerization by enantiomers of metal complexes was written by Liu, Li-Juan; Wang, Wanhe; Zhong, Zhangfeng; Lin, Sheng; Lu, Lihua; Wang, Yi-Tao; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 150699-10-8 The following contents are mentioned in the article:

The authors report herein the identification of an immunomodulatory metal-based complex 1 as a direct inhibitor of TLR1/2 heterodimerization. Both enantiomers of complex 1 selectively suppressed TNF-α and TLR1/2 heterodimerization in Pam3CSK4-induced macrophages, with Λ-1 being more potent than Δ-1. Moreover, the complexes inhibited NF-κB transduction via the modulation of TLR1/2 signaling. To the knowledge, complex 1 is the first metal-based inhibitor of TLR1/2 heterodimerization reported to date. This study involved multiple reactions and reactants, such as (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8Related Products of 150699-10-8).

(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 150699-10-8

150699-10-8;(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-10-8;New trend of C13H17NO2;function of 150699-10-8

Correction: Inhibition of TLR1/2 dimerization by enantiomers of metal complexes [Erratum to document cited in CA165:458094] was written by Liu, Li-Juan; Wang, Wanhe; Zhong, Zhangfeng; Lin, Sheng; Lu, Lihua; Wang, Yi-Tao; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Computed Properties of C13H17NO2 The following contents are mentioned in the article:

Correction for ′Inhibition of TLR1/2 dimerization by enantiomers of metal complexes′ by Li-Juan Liu et al., Chem. Commun., 2016, 52, 12278-12281. This study involved multiple reactions and reactants, such as (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8Computed Properties of C13H17NO2).

(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Computed Properties of C13H17NO2

150699-10-8;(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-10-8;New trend of C13H17NO2;function of 150699-10-8

(η3-Allyl)palladium complexes of chiral N,O-chelates: preparation, structures, and prospects for selective allylic functionalization was written by Yang, Hu; Khan, Masood A.; Nicholas, Kenneth M.. And the article was included in Organometallics on September 30,1993.Name: (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

A series of (η3-allyl)Pd derivatives of chiral N,O-bidentate ligands have been prepared and characterized to assess their potential as model intermediates for regio- and stereocontrolled catalytic allylic oxidation and substitution reactions. [N-(α-methylbenzyl)salicylaldimine]-Pd(η3-cyclohexenyl) (I), which exists in solution as a 1:1 Pd-allyl rotameric (exo/endo) mixture, selectively crystallizes as a single isomer. The X-ray crystal structure of this isomer of I shows nearly sym. Pd-allyl bonding parameters and the N-α-Ph group endo to the flap of the cyclohexenyl ring. The new chiral 4-substituted salicyloxazoline ligands and the corresponding (salicyloxazoline)Pd(η3-cyclohexenyl) complexes (II, R = Ph, CMe3, etc.; R1 = H, NO2, OMe; R2 = H, NO2) have been prepared in good yields by treatment of {(η3-cyclohexenyl)PdCl}2 with the K derivatives of the ligands. Solution NMR studies of II indicate that the ratio of isomers is a function of the size of the α-N substituent, with single isomers being present for R = tert-Bu. X-ray anal. of II (R = CMe3, R1 = R2 = H) reveals that the tert-Bu group and the cyclohexenyl flap are in an exo relationship with little evidence for a differential ground-state trans influence derived from the unsym. chelate. The terminal allylic proton NMR resonances of II (R = CMe3) are separated by ca. 0.4-0.5 ppm, suggesting different electronic characters for the two allylic carbons. Reactivity studies show that the complexes II are relatively unreactive toward HOAc, giving varying amounts of allylic acetate, and toward the nucleophiles OAc- and CH(CO2CH3)2-. This study involved multiple reactions and reactants, such as (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8Name: (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol).

(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Name: (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol

150699-10-8;(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-10-8;New trend of C13H17NO2;function of 150699-10-8

Chiral Pd-, Cu- and Ni-chelates and their utilities as catalysts in allylic acetoxylation of alkenes was written by Yang, Hu; Khan, Masood A.; Nicholas, Kenneth M.. And the article was included in Journal of Molecular Catalysis on July 29,1994.Related Products of 150699-10-8 The following contents are mentioned in the article:

A series of chiral ML*2 complexes of Pd, Cu and Ni [L = 2-trifluoroacetylcamphorato (tfacam), (R)-N-α-methylbenzylsalicylaldimine, 2-(2′-phenolato)-4-substituted oxazoline (phenox)] were prepared and characterized, including x-ray structures of Pd(tfacam)2 (1) and Pd(4-Ph-phenox)2 (3a). The Pd- and Cu-chelates are active (pre)catalysts for the allylic acetoxylation of alkenes. The yields and chemoselectivities in these reactions are high but little enantioselectivity (0-5%) was found. Several mechanistic probes, including tests of the stability of the product and PdL*2 under the reaction conditions, the product distribution from the acetoxylation of D-1-cyclohexene, and the low acetolysis reactivity of LPd(η3-allyl), indicate the intervention of (η3-allyl)-Pd intermediates in the catalytic process in which either or both L groups dissociate or at least dechelate in the product-forming step. This study involved multiple reactions and reactants, such as (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8Related Products of 150699-10-8).

(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Related Products of 150699-10-8

150699-10-8;(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-10-8;New trend of C13H17NO2;function of 150699-10-8