Category: 150699-08-4

Preparation of 2-[(4R)-4,5-dihydro-4-substituted-2-oxazolyl]-phenol derivatives useful as Henry reaction catalysts was written by Luo, Mei. And the patent was published on December 7,2011.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:

The invention relates to a process for the preparation of 2-[(4R)-4,5-dihydro-4-substituted-2-oxazolyl]-phenol derivatives I (R = i-Bu, Ph, or Bn), useful as Henry reaction catalysts. For instance, the compound I (R = Ph) was prepared by heterocyclization of o-cyanophenol with D-phenylglycinol in 60% yield. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Method for synthesis of diphenylphosphinic acid was written by Luo, Mei. And the patent was published on February 15,2012.Application of 150699-08-4 The following contents are mentioned in the patent:

The title method comprises preparing 2-[(4R/S)-4,5-dihydro-4-R-2-oxazolinyl]phenol or 2-[(4R/S)-4,5-dihydro-4-R-2-oxazolinyl]aniline, reacting with diphenylphosphinyl chloride in toluene in the presence of triethylamine for 2 days, filtering, evaporating, carrying out chromatog. with petroleum ether-dichloromethane (1:9) as eluent and volatilizing to obtain diphenylphosphonic acid crystal. The yield is about 5%. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Application of 150699-08-4).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Application of 150699-08-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

A chiral phosphonoamide ester compound and the preparation method thereof was written by Luo, Mei. And the patent was published on March 21,2012.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:

This patent supplies a chiral phosphonoamide ester compound, which is named 4H-1,3,2-phenyloxazolinyl phosphonoamide-2,3-dihydro-2-phenyl-3(R)-(R)-α-(chloromethyl)-2-oxide, in which R is selected form -CH2CH(CH3)2 or -Ph or -CH2Ph. The preparation method comprises reacting 2-cyanophenol and D-amino alc. in the presence of ZnCl2 under water and oxygen free condition in chlorobenzene under reflux for 24 h, reacting the obtained intermediate in mixture of benzene and pyridine under water and oxygen free condition and under reflux for 15 h to obtain title product. Title product is used as chiral catalyst, and has high catalytic activity and high selectivity. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem