Category: 145589-03-3

Reference of 145589-03-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.145589-03-3, Name is (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, molecular formula is C15H19NO3. In a Patent£¬once mentioned of 145589-03-3

1,8-dioxo -4,5-epoxy composition and method of making the same (by machine translation)

The present invention relates to 1,8-di-carbonyl -4,5-epoxy composition and method of making the same. Said 1,8-di-carbonyl -4, the structural formula of 5-epoxy compound is shown as formula 1 is shown. The compound 1 a step nitrogen substituted after folding open-loop and cyclization, can be highly selective, to obtain high yield of aliskiren key intermediate azido lactone compound. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 145589-03-3, and how the biochemistry of the body works.Reference of 145589-03-3

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2571NO – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Evans, David A. and a compound is mentioned, 145589-03-3, (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, introducing its new discovery. 145589-03-3

The Asymmetric Synthesis of alpha-Amino and alpha-Hydrazino Acid Derivatives via The Stereoselective Amination of Chiral Enolates with Azodicarboxylate Esters.

The utility of azodicarboxylate esters as (+)NH2 and (+)NH-NH2 synthons in highly diastereoselective reactions with chiral carboximide-derived enolates has been demonstrated.The lithium enolates derived from 4-substituted N-acyl 2-oxazolidinones were found to react with di-tert-butyl azodicarboxylate (DBAD) to afford the derived 2-hydrazido carboxylic acid derivetives in yields in excess of 90 percent.The diastereoselectivities of these reactions ranged from 97percent to greater than 99percent.The subsequent transformation of these adducts to both alpha-hydrazino and alpha-amino acids in enantiomeric purities in excess of 99percent is described.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 196603-96-0!, 145589-03-3

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Oxazolidine – Wikipedia,
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Let¡¯s face it, organic chemistry can seem difficult to learn. 145589-03-3. Especially from a beginner¡¯s point of view. Like 145589-03-3, Name is (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one. In a document type is Article, introducing its new discovery.

Functional analysis of an aspartate-based epoxidation catalyst with amide-to-alkene peptidomimetic catalyst analogues

Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The structure-dependent catalytic behavior of these isosteric peptides provides mechanistic insights in their mode of action. (Chemical Equation Presented).

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#REF!

To a solution of 5.6 g of N-isovaleroyl-(S)-4-benzyl-oxazolidin-2-one in 12 ml of toluene are added, at 00C, first of all 23.5 ml of a 1 -molar solution of bis-trimethylsilyl-lithium amide in tetrahydrofuran, then 5.7 g of dimethylpropylene urea. The solution obtained is added dropwise at 00C to a solution of 6 g of trans -1 ,4-dibromobut-2-ene in 10 ml of toluene. After stirring, the mixture is acidified with diluted hydrochloric acid, separated, and the organic solution concentrated. The crude product is purified by chromatography on a column of silica gel (eluant: hexane/ethyl acetate 85:15)., 145589-03-3

Other significant industrial processes that involve the use of heterogeneous catalysts include the preparation of sulfuric acid, the preparation of ammonia, the oxidation of ammonia to nitric acid, and the synthesis of methanol. 145589-03-3, if you are interested, you can browse my other articles.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/6532; (2007); A1;,
Oxazolidine – Wikipedia
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An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.(R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, cas is 145589-03-3. Here is a downstream synthesis route of the compound 145589-03-3. 145589-03-3

Intermediate 15: [(R)-4-BENZVL-3- (2-HYDROXYMETHYL-3-METHVL-BUTANOYL)-OXAZOLIDINONE] [4-BENZYL-3- (3-METHYLBUTANOYL)-OXAZOLIDINONE] (14) * (26. 1g, 0.1mol) was stirred in dry [DICHLOROMETHANE (400ML)] at [0C] under nitrogen as titanium tetrachloride (1. 0M solution in dichloromethane, 105ml, 0. [105MOL)] was added and the mixture, which contained a yellow precipitate, was stirred a further 15 minutes then [DIISOPROPYLETHYLAMINE (19ML, 0. 11MOL)] was added dropwise, maintaining the temperature below [5C.] The resulting purple solution was stirred for 75 minutes then 1,3, 5-trioxane (9.9g, [0.] 11mol) in [DICHLOROMETHANE] (60ml) was added, and after a further 10 minutes, titanium tetrachloride (1. [OM] in DCM, 105ml, 0. [105MOL)] was added. The mixture was stirred for 2.5 hours at [0C] then quenched by the addition of saturated ammonium chloride (500ml). Water (100ml) and [DICHLOROMETHANE] [(100ML)] were added, the aqueous phase extracted with a further 2 x [100ML DICHLOROMETHANE,] the combined organics dried over [NA2SO4] and evaporated. Recrystallisation from 30% [DICHLOROMETHANE/PETROLEUM] gave 18.7g (64%) of the title compound as a white solid. LCMS RT=2.94minutes [MH+ 292], 145589-03-3

Other significant industrial processes that involve the use of heterogeneous catalysts include the preparation of sulfuric acid, the preparation of ammonia, the oxidation of ammonia to nitric acid, and the synthesis of methanol. 145589-03-3, if you are interested, you can browse my other articles.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/104200; (2003); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.145589-03-3,(R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

EXAMPLE 6; Preparation of (S)-ie f-butyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4- methyl-pentanoate, compound (XVI) in which Z = terf-butyl.; A solution of hexyllithium 2.3 M in hexane (18.3 ml, 42.1 mmol) is added at 0 C and under nitrogen to a solution of diisopropylamine (5.19 ml, 42.1 mmol) in anhydrous tetrahydrofuran (10 ml). After 15 minutes the solution is cooled to -78 C and a solution of (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one (compound (XV), 10 g, 38.3 mmol), in THF (5 ml) is added dropwise. After 45 minutes at -78 C, terf-butylbromoacetate (10.7 ml, 72.7 mmol) is added. The temperature is raised to 20 C in 4 hours, then a saturated solution of ammonium chloride (50 ml) is added, the tetrahydrofuran is evaporated and the suspension thus obtained is extracted twice with ethyl acetate (2 x 100 ml). The combined organic phases are washed with 0.5N HCI, brine and are dried over sodium sulphate. After evaporating the solvent in a rotary evaporator, 16.48 g of raw product are obtained (orange-coloured solid), which is purified by flash chromatography (8:2 cyclohexane/ethyl acetate), obtaining 6.1 g of product as white solid (yield 50%). Alternatively the product can be purified by crystallizing the raw reaction product from isopropanol.1 H NMR (300 MHz, CDCI3, 298K) delta 7.37-7.20 (m, 5H), 4.70-4.60 (m, 1 H), 4.20- 4.08 (m, 3H), 3.35-3.25 (dd, J = 13.5 Hz, 3.1 Hz.1 H), 2.85-2.75 (dd, J = 28.9, 10.1 Hz, 1 H), 2.75-2.65 (dd, J = 13.8, 10.1 1 Hz, 1 H), 2.47-2.37 (dd, J = 16.8 Hz, 3.1 Hz, 1 H), 2.01 -1 .91 (m, 1 H), 1 .45-1 .35 (s, 9H).1 .05-0.95 (d, J = 6.7 Hz, 3H), 0.95-0.85 (d, J = 6.7 Hz, 3H).13C NMR (75 MHz, CDCI3, 298K) delta 176.8, 173.1 , 154.4, 137.1 , 130.5, 130.2, 178.3, 81 .6, 66.9, 57.0, 45.4, 38.5, 34.6, 31 .1 , 29.2, 21 .7, 19.5., 145589-03-3

As the paragraph descriping shows that 145589-03-3 is playing an increasingly important role.

Reference£º
Patent; CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo; WO2011/151442; (2011); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.145589-03-3,(R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

General procedure: A solution of sodium bis(trimethylsilyl)amide in n-hexane (1.03 M, 164 mL, 169 mmol) was added to a solution of 11c (32.9 g, 141 mmol) in THF (330 mL) under N2 atmosphere and at -78 C over 45 min, and the mixture was stirred at the same temperature for 30 min. Then, a solution of benzyl (2E)-4-bromobut-2-en-1-yl ether (35.5 g, 148 mmol) in THF (80 mL) was added to the above solution over 30 min, and the mixture was stirred at the same temperature for 30 min. The reaction mixture was raised to -40 C and further stirred for 4 h. Saturated NH4Cl aqueous solution (100 mL) was added to the reaction mixture, and the mixture was further stirred at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure and diluted with water (500 mL), followed by extraction with AcOEt. Then, the organic layer was washed with water and brine, and dried over anhydrous MgSO4. After filtration, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent, n-hexane/AcOEt = 7:1-2:1) to obtain (4S)-4-benzyl-3-[(2R,4E)-6-(benzyloxy)-2-methylhex-4-enoyl]-1,3-oxazolidin-2-one (37.9 g, 69%, 99% ee) as a colorless liquid., 145589-03-3

The synthetic route of 145589-03-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nakamura, Yuji; Fujimoto, Teppei; Ogawa, Yasuyuki; Namiki, Hidenori; Suzuki, Sayaka; Asano, Masayoshi; Sugita, Chie; Mochizuki, Akiyoshi; Miyazaki, Shojiro; Tamaki, Kazuhiko; Nagai, Yoko; Inoue, Shin-Ichi; Nagayama, Takahiro; Kato, Mikio; Chiba, Katsuyoshi; Takasuna, Kiyoshi; Nishi, Takahide; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 3175 – 3196;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

145589-03-3, (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 15: [(R)-4-BENZVL-3- (2-HYDROXYMETHYL-3-METHVL-BUTANOYL)-OXAZOLIDINONE] [4-BENZYL-3- (3-METHYLBUTANOYL)-OXAZOLIDINONE] (14) * (26. 1g, 0.1mol) was stirred in dry [DICHLOROMETHANE (400ML)] at [0C] under nitrogen as titanium tetrachloride (1. 0M solution in dichloromethane, 105ml, 0. [105MOL)] was added and the mixture, which contained a yellow precipitate, was stirred a further 15 minutes then [DIISOPROPYLETHYLAMINE (19ML, 0. 11MOL)] was added dropwise, maintaining the temperature below [5C.] The resulting purple solution was stirred for 75 minutes then 1,3, 5-trioxane (9.9g, [0.] 11mol) in [DICHLOROMETHANE] (60ml) was added, and after a further 10 minutes, titanium tetrachloride (1. [OM] in DCM, 105ml, 0. [105MOL)] was added. The mixture was stirred for 2.5 hours at [0C] then quenched by the addition of saturated ammonium chloride (500ml). Water (100ml) and [DICHLOROMETHANE] [(100ML)] were added, the aqueous phase extracted with a further 2 x [100ML DICHLOROMETHANE,] the combined organics dried over [NA2SO4] and evaporated. Recrystallisation from 30% [DICHLOROMETHANE/PETROLEUM] gave 18.7g (64%) of the title compound as a white solid. LCMS RT=2.94minutes [MH+ 292], 145589-03-3

145589-03-3 (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one 11391340, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/104200; (2003); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

145589-03-3, (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of (S)-4-benzyl-3-(3-methylbutyryl)-2-oxazolidinone (13.0 g, 50 mmol), which is prepared according to Rueger et a/ Tetrahedron Letters (2000), 41 (51), 10085-10089, in dry THF at -78 0C is added LiHMDS (55 mL, 1.0 M in toluene, 55 mmol) and the solution is stirred at 0 0C for 30 minutes before cooling down to -78 0C. AIIyI bromide (4.0 mL, 55 mmol) is then added and the mixture is stirred at room temperature for 2 hours. The products are extracted with EtOAc, washed with saturated aqueous NH4CI, water and saturated aqueous NaCI, dried (MgSO4) and evaporated to give a yellow oil which is purified by flash chromatography on silica gel eluting with 10% EtOAc/hexane to give IVA as a colourless oil. 1H NMR (400.13 MHz, CDCI3) delta 0.91 (d, 6H, J = 6.8 Hz), 1.8-2.0 (m, 1 H), 2.2-2.5 (m, 2H), 2.57 (dd, 1 H1 J = 13.3, 10.1 Hz), 3.25 (dd, 1 H, J = 13.3, 3.2 Hz), 3.7-3.9 (m, 1 H), 4.0-4.1 (m, 2H), 4.5-4.7 (m, 1H), 4.95 (d, 1 H, J = 10.2 Hz), 5.02 (dq, 1 H, J = 17.1 , 1.5 Hz), 5.7-5.8 (m, 1 H), 7.1-7.3 (m, 5H) ppm., 145589-03-3

As the paragraph descriping shows that 145589-03-3 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; WO2008/155338; (2008); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.145589-03-3,(R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

THE 3 (S)-ISOPROPYL-5 (S)-1(S)-AZIDO-3 (S)-ISOPROPYL-4-OXO-butyl-tetrahydrofuran-2-one used in step d) is prepared as follows: g) 2 (S), 7 (S) -Diisopropyl-oct-4-ene-dicarboxylic acid [bis (4 (S) -benzyl-oxazolidin-2-one)]-amide 48 ml of a 1.0 M solution of lithium hexamethyldisilazide in tetrahydrofuran are added dropwise, with stirring, AT-75C,] within a period of one hour, to a solution of 11.5 g of 4 (S)- benzyl-3-isovaleroyl-oxazolidin-2-one in 32 ml of tetrahydrofuran. The mixture is stirred further for 2 hours at- [75C] and for 20 minutes [AT-20C,] and there are then added thereto 10 ml of 1, 3-dimethyl-3,4, 5,6-TETRAHYDRO-2- (1H)-pyrimidone (DMPU) and, within a period of 45 minutes, a solution of 4.28 g of 1, 4-dibromo-2-butene in 10 ml of tetrahydrofuran. The reaction mixture is stirred for a further 15 hours AT-20C and is then brought to [0C] within a period of one hour; 10 ml of saturated ammonium chloride solution are then added thereto at- [20C] and, after 15 minutes, the mixture is brought to room temperature. The reaction mixture is then partitioned between dichloromethane and saturated sodium chloride solution/water=1 : 1. The organic phases are combined, dried over sodium sulfate and concentrated by evaporation, and the residue is purified by means of FC (hexane/ethyl acetate=4: 1), yielding the title compound: Rf (hexane/ethyl acetate=4: 1) =0.30 ; HPLC Rt =21.6 minutes; FAB-MS (M+H) [+] =575; m. p. [=110-111C.], 145589-03-3

As the paragraph descriping shows that 145589-03-3 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; WO2003/103653; (2003); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem