Category: 133812-16-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133812-16-5,(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

Method two: replace the nitrogen reaction bottle,24.5 g (0.1 mol) of intermediate (I) and 400 ml of anhydrous dichloromethane are added and the temperature is lowered to -50C to -60C,120 ml (0.12 mol) of a 1 M solution of titanium tetrachloride in dichloromethane are slowly added dropwise.Then 46.3 ml (0.24 mol) of N,N-tetramethylethylenediamine and 19.4 ml (0.2 mol) of N-methylpyrrolidone are added dropwise,The stirring was completed for 30 minutes.A solution of 19.5 g (0.2 mol) of 2,5-difluorobenzaldehyde in 70 ml of dichloromethane was slowly added dropwise and stirred for 2 h.The reaction temperature was slowly raised to 15C.TLC showed that the reaction was complete, add saturated ammonium chloride, filter, separate the organic layer, and wash with saturated sodium bicarbonate.After drying and silica gel column chromatography, 34.8 g of intermediate (II) was isolated with a yield of 90%.

As the paragraph descriping shows that 133812-16-5 is playing an increasingly important role.

Reference£º
Patent; Zhong Guifa; Wu Yiwu; Lan Xiaobing; (12 pag.)CN107459501; (2017); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

133812-16-5, (S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a reaction tube containing olefin (0.15 mmol), hypervalent iodine(III) catalyst 1 (16.7 mg, 0.03 mmol) and aldehyde 2 (0.225 mmol) were mixed in appropriate solvent (2.4 M) under argon atmosphere. The mixture was irradiated by UV light (365 nm) with stirring for 12 ~ 48 h. After completion of the reaction, solvent was removed under reduced pressure. The crude product was purified by flash column chromatography (eluting with hexane/ethyl acetate = 20:1 to 4:1) to afford the corresponding hydroacylated products. The diastereoselectivity of the products was calculated from 1H NMR spectra of crude products. The spectral data of 4 and 5 were consistent with the previously reported data.

133812-16-5 (S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one 5702600, aoxazolidine compound, is more and more widely used in various.

Reference£º
Article; Selvakumar, Sermadurai; Kang, Qi-Kai; Arumugam, Natarajan; Almansour, Abdulrahman I.; Kumar, Raju Suresh; Maruoka, Keiji; Tetrahedron; vol. 73; 40; (2017); p. 5841 – 5846;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem