Category: 1194-22-5

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthetic modification and scale-up process for 1,1-diamino-2,2-dinitroethene (FOX-7)》. Authors are Chung, Kyoo-Hyun; Goh, Eun Mee; Cho, Jin Rai.The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).Recommanded Product: 1194-22-5. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

Many different synthetic routes to FOX-7 were developed until now. Each starting material such as 2-methylimidazole, 2-methoxy-2-methylimidazolidine-4,5-dione, or 2-methylpyrimidine-4,6-dione (4,6-dihydroxy-2-methylpyrimidine), was nitrated and then hydrolyzed to FOX-7 by somewhat different process, but the yields were more or less low and the processes were felt a little boring. In the modified process from 4,6-dihydroxy-2-methylpyrimidine, FOX-7 was synthesized in about 90% yield within several hours. The reaction temperature was well controlled in the preparation of 4,6-dihydroxy-2-methylpyrimidine, while some heat was evolved at the beginning of nitration, judging from a reaction calorimeter.

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Patil, R. S.; Jadhav, P. M.; Radhakrishnan, S.; Soman, T. published the article 《Process chemistry of 4, 6-dihydroxy-2-methylpyrimidine-A potential precursor in pharmaceutical and explosive industries》. Keywords: dihydroxy methylpyrimidine A pharmaceutical explosive industry.They researched the compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ).Related Products of 1194-22-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1194-22-5) here.

4,6-Dihydroxy-2-methylpyrimidine is an important precursor, finding widespread applications in the preparation of high explosives and medicinal products. The synthesis of 4,6-dihydroxy-2-methylpyrimidine has been carried out by the condensation of acetamidinium chloride and di-Et malonate in absolute methanol and further acidified by hydrochloric acid. Process chem. has been studied by using various alcs., alkoxides and effect of reaction period. The role of process variables and parameters has been understood thoroughly and developed an economic process. Modified process yielded the product without compromising on its quality, which was confirmed by spectroscopic techniques and elemental anal. Hence, the study finds its usefulness in the development of an economic process for the production of 4,6-dihydroxy-2-methylpyrimidine.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Energetic Salts with π-Stacking and Hydrogen-Bonding Interactions Lead the Way to Future Energetic Materials, published in 2015-02-04, which mentions a compound: 1194-22-5, Name is 6-Hydroxy-2-methylpyrimidin-4(3H)-one, Molecular C5H6N2O2, Application of 1194-22-5.

Among energetic materials, there are two significant challenges facing researchers: (1) to develop ionic CHNO explosives with higher densities than their parent nonionic mols. and (2) to achieve a fine balance between high detonation performance and low sensitivity. We report a surprising energetic salt, hydroxylammonium 3-dinitromethanide-1,2,4-triazolone, that exhibits exceptional properties, viz., higher d., superior detonation performance, and improved thermal, impact, and friction stabilities, then those of its precursor, 3-dinitromethyl-1,2,4-triazolone. The solid-state structure features of the new energetic salt were investigated with X-ray diffraction which showed π-stacking and hydrogen-bonding interactions that contribute to closer packing and higher d. According to the exptl. results and theor. anal., the newly designed energetic salt also gives rise to a workable compromise in high detonation properties and desirable stabilities. These findings will enhance the future prospects for rational energetic materials design and commence a new chapter in this field.

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Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Investigation of FOX-7 Polymorphs: new polymorphs – ε and ζ. Author is Kushtaev, Alexander A.; Yudin, Nikolay V.; Kondakova, Natalia N.; Ilicheva, Natalia N.; Vu, Tuan Q.; Zbarskiy, Vitold L..

Polymorphism of 1,1-diamino-2,2-dinitroethene (FOX-7, DADNE) has investigated by X-ray powder diffraction (XRD), differential scanning calorimetry (DSC), thermo gravimetric anal. (TGA), IR-spectroscopy. Two previously unknown polymorph modifications of FOX-7 – ε and ζ were discovered. ε-FOX-7 has prepared by hydrolysis of 2-(dinitromethylene)-5,5-dinitropyrimidine-4,6(1H,3H,5H)-dione in a media with pH up 7-8 to Ho≈-3 and 2-(dinitromethylene)imidazolidine-4,5-dione in aqueous ammonia. Ε-FOX-7 is a stable and exists in temperature range 273-378 K. ζ-polymorph of FOX-7 can be obtained at ε-FOX-7 heating to 378-380 K. ζ→ε polymorph transition is a reversible and occurs at 361.7±3.1 K. At 433-453 K ζ-FOX-7 transforms to γ-polymorph. ζ→γ phase transition temperature range was determined using IR-spectroscopy because it is invisible on DSC curves. IR-spectra of ε and ζ polymorphs are significantly distinct from α-, β- and γ-FOX-7. ε-FOX-7, in contrast to monoclinic α-polymorph, has orthorhombic type of crystal system (space group P212121). Based on received data, new scheme of FOX-7 polymorph transition is proposed.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Application of 1194-22-5.Astrat’ev, A. A.; Dashko, D. V.; Mershin, A. Yu.; Stepanov, A. I.; Urazgil’deev, N. A. published the article 《Some specific features of acid nitration of 2-substituted 4,6-dihydroxypyrimidines. Nucleophilic cleavage of the nitration products》 about this compound( cas:1194-22-5 ) in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). Keywords: nitration pyrimidinediol; nitropyrimidine preparation hydrolysis; nitroethylenediamine preparation. Let’s learn more about this compound (cas:1194-22-5).

The nitration of 2-substituted 4,6-dihydroxypyrimidines in concentrated sulfuric acid yields the corresponding 5,5-dinitro derivatives When the substituent in position 2 is an alkyl group, the nitration occurs both at position 5 and at the α-carbon atom of the side chain. Hydrolysis of 2-substituted 4,6-dihydroxy-5,5-dinitropyrimidines leads to formation of 1,1-diamino-2-R-2-nitroethylene derivatives 1,1-Diamino-2,2-dinitroethylene was obtained by nitration of 4,6-dihydroxy-2-methylpyrimidine and subsequent hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-(dinitromethylene)-2,5-dihydropyrimidine.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Pyrimidines. IV. 2-, 5-, and 2,5-substituted chloropyrimidines, the main research direction is ANTINEOPLASTIC AGENTS; CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; LEUKEMIA L1210; MICE; NEOPLASMS, EXPERIMENTAL; PHARMACOLOGY; PYRIMIDINES; SARCOMA 180, CROCKER; TISSUE CULTURE.Recommanded Product: 1194-22-5.

cf. CA 58, 9061g. Condensation of the appropriate amidine or urea with the corresponding Et malonate in the presence of NaOEt and the 4,6-pyrimidinediol treated with POCl3, POCl3-PhNMe2, or POCl3-PCl5 gave the Cl-substituted pyrimidines. The amidines were prepared according to Pinner [Ber. 17, 171(1884)], and details were given for preparation of anhydrous PhC(: NH)NH2.HCl, in 37.6% yields. Pertinent data on the 2-, 5-, and 2,5-substituted pyrimidines (I) and uv spectra data for the ring-polychlorinated pyrimidines were summarized. I (R = Me, R1 = Cl, R2 = Me, R3 = Cl) and I (R = ClCH2, R1 = Cl, R2 = Me, R3 = Cl) were converted to the 5-bromomethyl derivatives by treatment with (CH2CO)2NBr in the presence of Bz2O2. All compounds were screened against at least 3 mouse tumors and the data tabulated. A series of 5-substituted 2,4,6-trichloropyrimidines showed confirmed activity in the KB cell culture test system and the screening data were summarized.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Simple pyrimidines. VII. The fine structure of 4,6-dihydroxypyrimidine》. Authors are Brown, D. J.; Teitei, T..The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).Product Details of 1194-22-5. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

cf. CA 59, 11490g. The ultraviolet spectrum of 4,6-dihydroxypyrimidine was compared with those of N-, O-, and 5-alkylated derivatives of fixed structures corresponding to possible tautomeric forms. Ultraviolet spectra in aqueous buffer of neutral mols. of 5,5-diethyl-1,4,5,6-tetrahydro-1,2-dimethyl-4,6-dioxopyrimidine, 4,6-dihydroxypyrimidine, 1,6-dihydro-4-methoxy-1-methyl-6- oxopyrimidine, 4,6-dimethoxypyrimidine, and 1,4-dihydro-6-methoxy-1-methyl-4-oxopyrimidine and ultraviolet spectra in alc. of 4,6-dihydroxy-5-methylpyrimidine, 4,6-dihydroxy-5-isopropylpyrimidine, 4,6-dihydroxy-2-n-propylpyrimidine, and 4,6-dihydroxypyrimidine were determined An aqueous solution consisted essentially of 1,4,5,6-tetrahydro-4,6-dioxopyrimidine in equilibrium with a smaller amount of 1,4-dihydro-6-hydroxy-4-oxopyrimidine. The existence of the active 5-methylene grouping within the ring was confirmed chem. by a ready condensation of benzaldehyde with the pyrimidine in aqueous solution

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Kushtaev, A. A.; Djakonov, A. V.; Yudin, N. V.; Zbarsky, V. L. published an article about the compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O ).Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1194-22-5) through the article.

6-Hydroxy-2-methylpyrimidine-4(3H)-one is known to be used as a precursor in the synthesis of FOX-7 via nitration reaction. In this connection we studied the nitration kinetics of 6-hydroxy-2-methylpyrimidine-4(3H)-one in sulfuric-nitric acid mixtures A byproduct reaction leading to a decrease in the yield of 2-(dinitromethylene)-5,5-dinitropyrimidine-4,6(1H,3H,5H)-dione was revealed. The data obtained allowed a scheme of the nitration process, which included three consecutive reactions. The reaction rate constants were obtained for each of the stages.

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