Category: 1194-22-5

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Kinetic and spectral investigation of the electron and hydrogen adducts of dihydroxy- and dimethyl-substituted pyrimidines: A pulse radiolysis and product analysis study.COA of Formula: C5H6N2O2.

The reactions of hydrated electrons (eaq-) and hydrogen atoms (H•) with 4,6-dihydroxy-2-methylpyrimidine (DHMP), 2,4-dimethyl-6-hydroxypyrimidine (DMHP), 5,6-dimethyluracil (DMU) and 6-methyluracil (MU) were studied at different pH values using pulse radiolysis. The second-order rate constants obtained for the reaction of eaq- with these systems are in the range (5-10) × 109 dm3 mol-1 s-1 at near, neutral pH. At basic pH, the rate constant values were considerably reduced owing to the electrostatic effect between eaq- and pyrimidine anion. The transient absorption spectra of the electron adducts have distinct absorption maxima at around 300-320 nm. The initial spectrum in the case of DHMP at pH 4.5 was found to undergo a first-order transformation. Based on the spectral characteristics and the yields of methylviologen radical cation (MV.+) resulted from the electron transfer reaction between the electron adducts and MV2+, it is proposed that a protonated (at oxygen) electron adduct of DHMP is initially formed which undergoes a proton- and phosphate-catalyzed transformation to form a reducing C(5) protonated C(6)-yl radical. Such preferential protonation at C(5) is predominant only with dihydroxypyrimidine systems. At pH 9 and 13, formation of a radical monoanion of DHMP (pKa ≥ 13) is proposed. The possible attack of eaq- is proposed to be at N(1) or N(3) of DMHP. The resulting electron adduct has a pKa value around 6.0. Similar properties for the electron adducts of DMU and MU [electron attack at O(4)] are proposed. The second-order rate constants for H. with DHMP, DMHP, DMU and MU were in the range (1.7-28) × 108 dm3 mol-1 s-1. The hydrogen adduct spectra were generally identified as their absorption maxima at 310-380 and 460-510 nm. Formation of C(5)-protonated C(6)-yl radical, the same radical that formed after the H+-and phosphate-catalyzed transformation of the electron adduct, is proposed for DHMP. The possibility of the formation of C(5)-yl and C(6)-yl H adducts of DMHP, DMU and MU is discussed. High-performance liquid chromatog. coupled with electrospray mass spectrometry (HPLC-ES-MS) has been used to qual. analyze the products obtained from the reaction of eaq- with DHMP and DMHP and the results revealed that the products are mainly derived from the C(5) protonated C(6)-yl radicals via its disproportionation and dimerization reaction. A possible reaction mechanism is proposed for the product formation.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Related Products of 1194-22-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Novel dinitromethyl-featured polynitro energetic salts. Author is Li, Ying; Huang, Haifeng; Lin, Xiangyang; Pan, Renming; Yang, Jun.

A unique and facile method was developed to synthesize a new class of energetic salts based on 2-amino-1,1,5,5-tetranitro-4-oxo-3-aza-pentene. All the salts were fully characterized by NMR (1H and 13C), IR spectroscopy and elemental anal. Furthermore, the crystal structure of the guanidinium salt was determined by single-crystal X-ray diffraction. The differential scanning calorimetry (DSC) results showed that the decomposition temperatures of these salts were between 126.2 °C and 148.8 °C. The densities of these salts lie in the range of 1.745 to 1.880 g cm-3. Their impact sensitivities and friction sensitivities were measured to be in the range of 1-16 J and 48-84 N, resp. All the salts exhibited promising detonation performances (detonation pressure: 28.6 to 34.3 GPa; detonation velocity: 8037 to 8674 m s-1), and the detonation performances of one of the salts were comparable to those of RDX.

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Oxazolidine – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1194-22-5, is researched, Molecular C5H6N2O2, about Methyl 2-(benzoylamino)-3-(dimethylamino)propenoate in the synthesis of fused pyranones. The synthesis of derivatives of tetrahydro-2H-1-benzopyran-2-one, isomeric 2H-naphtho[1,2-b]pyran-2-one and 3H-naphtho[2,1-b]pyran-3-one, pyrano[3,2-c]benzopyran-2,5-dione, and 7H-pyrano[2,3-d]pyrimidin-7-one, the main research direction is benzoylaminodimethylaminopropenoate cyclocondensation diketone; pyranone fused; benzopyranone tetrahydro; naphthopyranone; pyranobenzopyrandione; pyranopyrimidinone.Electric Literature of C5H6N2O2.

Me 2-benzoylamino-3-dimethylaminopropenoate (I) reacts with carbocyclic and heterocyclic 1,3-diketones or potential 1,3-diketones, such as 1,3-cyclohexanediones, and 4-hydroxy-2H-1-benzopyran-2-one derivatives, in acetic acid to afford the corresponding 3-benzoylamino substituted 5-oxo-5,6,7,8-tetrahydro-2H-benzopyran-2-ones, and 2H,5H-pyrano[3,2-c][1]benzopyran-2,5-dione derivatives. 1-Naphthol and 2-naphthol produce the isomeric 2H-naphtho[1,2-b]pyran-2-one and 3H-naphtho[2,1-b]pyran-3-one derivatives, resp. Et cyclopentanone-2-carboxylate and Et cyclohexanone-2-carboxylate do not react under these conditions, while in polyphosphoric acid the cyclization of the reagent I is taking place to give 4-dimethylaminomethylene-2-phenyl-5(4H)-oxazolone. 4,6-Dihydroxypyrimidine derivative I affords in acetic acid the noncyclized intermediate II, which can be further transformed in polyphosphoric acid into 7H-pyrano[2,3-d]pyrimidin-7-one derivative III.

From this literature《Methyl 2-(benzoylamino)-3-(dimethylamino)propenoate in the synthesis of fused pyranones. The synthesis of derivatives of tetrahydro-2H-1-benzopyran-2-one, isomeric 2H-naphtho[1,2-b]pyran-2-one and 3H-naphtho[2,1-b]pyran-3-one, pyrano[3,2-c]benzopyran-2,5-dione, and 7H-pyrano[2,3-d]pyrimidin-7-one》,we know some information about this compound(1194-22-5)Electric Literature of C5H6N2O2, but this is not all information, there are many literatures related to this compound(1194-22-5).

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.Chen, Hanping; Lin, Guiying; Chen, Yingquan; Chen, Wei; Yang, Haiping published the article 《Biomass Pyrolytic Polygeneration of Tobacco Waste: Product Characteristics and Nitrogen Transformation》 about this compound( cas:1194-22-5 ) in Energy & Fuels. Keywords: biomass pyrolysis polygeneration tobacco waste nitrogen transformation. Let’s learn more about this compound (cas:1194-22-5).

Conversion of waste to high-value products by pyrolysis is a suitable and harmless disposal technol. for the abundant waste generated in the tobacco industry. To determine the optimum operational parameters for biomass pyrolytic polygeneration using tobacco waste as the feedstock, the product characteristics and N transformation were studied from 250 to 950°. The highest low calorific values of gas and char were 13 MJ/m3 at 750° and 15 MJ/kg at 450°, resp. The optimum operating temperature recommended for biomass pyrolytic polygeneration of tobacco waste is 650° when the 3 products (char, oil, and gas) are balanced. The char formation process is divided into 3 stages: degradation (250-450°), reforming (450-650°), and condensation (>650°). Three types of N-containing structures are formed in chars: pyridinic N, pyrrolic/pyridine N, and quaternary N. Pyridinic N is dominant at low temperatures, whereas quaternary N becomes dominant at high temperatures N-containing volatiles escape from chars with increasing temperature and are primarily found in oil <550° and in gas >650°. N-containing compounds are the major components (up to 45%) in the organic portion of oil, with pyridines, pyrroles, and piperidines as the dominant forms. In the gas product, NH3 and HCN are the major N-containing compounds released >650°. This study is expected to be beneficial for the comprehensive use of tobacco waste.

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Oxazolidine – Wikipedia,
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Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Spectroscopic Study of the Basicity of 4,6-Dihydroxypyrimidine Derivatives. Author is Vu, Tuan Q.; Yudin, Nikolai V.; Kushtaev, Alexander A.; Nguyen, Thanh X.; Maltsev, Sergey A..

The protonation of a number of 4,6-dihydroxypyrimidine derivatives is studied, and the features of the electronic spectra of free bases and protonated forms are considered. It is shown that the alkyl substituents in position 2 increase the basicity of the compound, and the nitro group in position 5 leads to its decrease. In an acid medium (0.1-99.5% H2SO4), 4,6-dihydroxypyrimidine, 6-hydroxy-2-methylpyrimidine-4(3H)-one, and 6-hydroxy-2-ethylpyrimidine-4(3H)-one have two protonation stages, barbituric acid is protonated in three stages, and 6-hydroxy-2-methyl-5-nitropyrimidine-4(3H)-one and 6-hydroxy-2-ethyl-5-nitropyrimidine-4(3H)-one form a monocation.

From this literature《Spectroscopic Study of the Basicity of 4,6-Dihydroxypyrimidine Derivatives》,we know some information about this compound(1194-22-5)Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, but this is not all information, there are many literatures related to this compound(1194-22-5).

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Oxazolidine – Wikipedia,
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Formula: C5H6N2O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Synthesis, spectral characterizations and biological applications of novel 3-[(E)-(4, 6-dihydroxy pyrimidin-5-yl)diazenyl]-4-methylbenzoic acid azo Dye and their derivatives. Author is Prashantha, A. G.; Keshavayya, J.; Shoukat Ali, R. A..

Novel derivatives of amino-methylbenzoic acid and Pyrimidine-4,6-diol based heterocyclic azo dyes (5-7) were reported. Synthesis was carried out by diazotization of amino-methylbenzoic acid (1) and followed by coupling with different derivatives of Pyrimidine-4,6-diol based coupling components such as Pyrimidine-4,6-diol(2), 2-Me pyrimidine-4,6-diol(3), 2-aminopyrimidine-4,6-diol(4) under suitable exptl. condition. The azo dyes obtained are orange-red in color and they are characterized by various anal. methods like IR, UV-Vis, 1H NMR, 13C NMR and Mass spectral techniques etc. The synthesized compounds were screened for their biol. activities and the result was compared with the standards

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Formula: C5H6N2O2, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.Goh, Eun Mee; Kim, Hyoun-Soo published the article 《The scale up process improvement of 1,1-diamino-2,2-dinitroethane (DADNE)》 about this compound( cas:1194-22-5 ) in New Trends in Research of Energetic Materials, Proceedings of the Seminar, 13th, Pardubice, Czech Republic, Apr. 21-23, 2010. Keywords: explosive diaminodinitroethane synthesis scaleup safety. Let’s learn more about this compound (cas:1194-22-5).

1,1-Diamino-2,2-dinitroethane (DADNE) is a novel explosive with low sensitivity and high performance. The nitration process of 4,6-dihydroxy-2-Me pyrimidine was enhanced using organic solvent. The temperature of reaction in nitration step is preferably 20-40°. The reaction time of step is 2 h. After nitration process, for the hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-dinitromethylene-2,5-dihydropyrimidine, wherein heating reactant is applies in the hydrolysis, thereby solving the safety problem while improving the reaction time of hydrolysis.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about ESR studies of electron and hydrogen adducts of thymine and uracil and their derivatives and of 4,6-dihydroxypyrimidines in aqueous solution. Comparison with data from solid state. The protonation at carbon of the electron adducts.

The coupling constants of the radicals produced in aqueous solution by reaction of the hydrated electron with uracil and thymine and with their nucleosides and nucleotides were determined using the in situ radiolysis ESR method. From the coupling constants of these electron adducts it is evident that the unpaired spin d. at C(6) of the pyrimidine ring is much larger than that at C(5). Substitution with Me, carboxyl, or ribosyl groups at C(5), C(6), and N(1), resp., has little effect on the distribution of the unpaired spin. The splittings of the radicals measured in aqueous solution are very similar to those previously reported for the same radicals in the solid state, which shows that the latter data are of predictive value also for the aqueous phase. At pH 7 in the presence of phosphate the electron adducts are converted into 6-dihydropyrimidin-5-yl radicals by protonation on C(6). The protonation reaction has previously been observed to occur in the solid state. In comparison, the hydrogen atom reacts with uracil to give the 5-dihydro-6-yl radical. The uracil isomer 4,6-dihydroxypyrimidine, and its 2- and 5-Me derivative react with the hydrated electron to give delocalized radical anions, which on protonation by H+ are converted into the 5-dihydro-2-yl radicals. This conversion, which can also be catalyzed by phosphate, is more efficient than in the case of uracil. The hydrogen atom reacts with the 4,6-dihydroxypyrimidine system by addition at C(5) to give the same radical as that from the reaction with the hydrated electron followed by protonation. With the electron adduct of 4,6-dihydroxypyrimidine, a OH- catalyzed protonation by water on C(5) is observed

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Application In Synthesis of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about The nitration peculiarity of 6-hydroxy-2-methylpyrimidine-4(3H)-one to 6-hydroxy-2-methyl-5-nitropyrimidine-4(3H)-one. Author is Kushtaev, A. A.; Yudin, N. V.; Zbarsky, V. L..

The nitration kinetic of 6-hydroxy-2-methylpyrimidine-4(3H)-one to 6-hydroxy-2-methyl-5-nitropyrimidine-4(3H)-one was studied in sulfuric-nitric acid mixtures The dependences of rate constants from medium acidity and nitric acid concentration were obtained. The nitrogen oxides influence was discovered on this process. The basicity constant of 6-hydroxy-2-methylpyrimidine-4(3H)-one was calculated.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Properties of the OH Adducts of Hydroxy-, Methyl-, Methoxy-, and Amino-Substituted Pyrimidines: Their Dehydration Reactions and End-Product Analysis.Recommanded Product: 1194-22-5.

Reactions of hydroxyl radicals (•OH) with 2-amino-4-methylpyrimidine (AMP), 2-amino-4,6-dimethylpyrimidine (ADMP), 2-amino-4-methoxy-6-methylpyrimidine (AMMP), 2-amino-4-hydroxy-6-methylpyrimidine (AHMP), 4,6-dihydroxy-2-methylpyrimidine (DHMP), 2,4-dimethyl-6-hydroxypyrimidine (DMHP), 6-methyluracil (MU), and 5,6-dimethyluracil (DMU) have been studied by pulse radiolysis and steady-state radiolysis techniques at different pH values. The second-order rate constants of the reaction of •OH with these systems are of the order of (2-9) × 109 dm3 mol-1 s-1 at near neutral pH. The difference in the spectral features of the intermediates at near neutral pH and at higher pH (10.4) obtained with these pyrimidines are attributed to the deprotonation of the OH adducts. The G(TMPD•+) obtained at pH ∼ 6, from the electron-transfer reactions of the oxidizing intermediates with the reductant, N,N,N’,N’-tetramethyl-p-phenylenediamine (TMPD), are in the range (0.2-0.9) × 10-7 mol J-1 which constituted about 3-16% oxidizing radicals. These yields were highly enhanced at pH 10.5 in the case of AHMP, DHMP, DMU, and MU [G(TMPD•+) = 3.8-5.5 equivalent 66-95% oxidizing radical]. On the basis of these results, it is proposed that a nonoxidizing C(6)-ylC(5)OH radical adduct is initially formed at pH 6 which is responsible for the observed transient spectra. The high yield of TMPD•+ at higher pH is explained in terms of a base-catalyzed conversion (via a dehydration reaction) of the initially formed C(6)-ylC(5)OH adduct (nonoxidizing) to C(5)-ylC(6)OH adduct which is oxidizing in nature. Among the selected pyrimidines, such a dehydration reaction was observed only with those having a keto (or hydroxy) group at the C(4) position of the pyrimidine ring. Qual. analyses of the products resulting from the OH adducts of DHMP (at pH 4.5) and DMHP (at pH 6) were carried out using HPLC-ES-MS and a variety of products have been identified. Glycolic and dimeric products were observed as the major end-products. The product profiles of both DHMP and DMHP have shown that the precursors of the products are mainly the C(6)-ylC(5)OH and the H adduct radicals. The identified products are formed mainly by disproportionation and dimerization reactions of these radicals. The mechanistic aspects are discussed.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem