Category: 1194-22-5

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Experimental therapy of stomach ulcers in rats》. Authors are Akimov, A. A.; Pazarev, N. V..The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

Gastric ulcers were induced in rats by repeated administration of caffeine by a gastric sonde. Animals were then treated with 4-methyluracil (I), dihydrouracil, dihydro-4-methyluracil, 5-hydroxy-4-methyluracil, thymine, 4,6-dihydroxypyrimidine (II), 2-methyl-4,6-dihydroxypyrimidine (III), cytosine (IV), 4-amino-6-hydroxypyrimidine, or 2-amino-6-oxy-4-methylpyrimidine (all compounds given by gastric sonde, 50 mg./kg.). A 42-72% reduction of ulcers followed the treatment of animals with I, II, III, and IV; with all other compounds the effect was not significant. Combined treatment of rats with I and III, or I and IV was most effective. Higher doses of all compounds tested had a smaller therapeutic effect. Pyrimidines apparently stimulate regenerative processes and thus complement the effect of other therapeutics in the treatment of gastric ulcers.

This compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Category: oxazolidine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about An efficient and convenient synthesis of 4,6-dichloro-2-methyl-5-nitropyrimidine. Author is Zhou, Shuwen; Xu, Defeng; Wang, Ziqiao; Zhu, Zhiling; Zha, Zhenyu; Fan, Yu; Su, Hongkui.

A convenient synthesis of 4,6-dihydro-2-methylpyrimidine can be obtained by cyclization reaction of acetamidine hydrochloride and di-Et malonate in the presence of sodium methoxide for a 91.2% yield. 4,6-Dihydro-2-methyl-5-nitropyrimidine achieved by nitration under the mixed acids of nitric acid, trichloroacetic acid and acetic acid in an 88.3% yield and then the chlorination using phosphorus oxytrichloride can afford 4,6-dichloro-2-methyl-5-nitropyrimidine with an 82.6% yield.

This compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Category: oxazolidine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

SDS of cas: 1194-22-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Synthesis of triple [14C]-labeled moxonidine. Author is Czeskis, Boris A..

The synthesis of radiolabeled antihypertensive compound [14C3]moxonidine I was accomplished based on condensation of [1-14C]acetamidine with di-Et [1,3-14C2]malonate to form [2,4,6-14C3]-4,6-dihydroxy-2-methylpyrimidine. Subsequent nitration, chlorination, and hydrogenation of the latter gave [2,4,6-14C3]-4,6-dichloro-2-methyl-5-aminopyrimidine. The final product was obtained after the coupling of the above aminopyrimidine with 1-acetylimidazolidin-2-one, followed by hydrolysis using sodium methoxide.

This compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)SDS of cas: 1194-22-5 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Electric Literature of C5H6N2O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Effect of pyrimidine derivatives on the incorporation of labeled amino acids into liver proteins. Author is Lifshits, R. I.; Kamilov, F. Kh..

Uracil [66-22-8], cytosine [71-30-7], 6-hydroxy-2,4-dimethylpyrimidine [6622-92-0], 4,6-dihydroxy-2-methylpyrimidine [1194-22-5], 2-amino-6-hydroxy-4-methylpyrimidine [3977-29-5], or 2,5-diamino-6-hydroxy-4-methylpyrimidine [4214-86-2] increased 14C-labeled alanine [56-41-7] incorporation into proteins of the mitochondria-free liver cell fraction when injected i.p. at 100 mg/kg into rats, added at 0.6 mM to the perfusion liquid of the isolated rat liver, or incubated at 0.6 mM with the liver tissue. Orotic acid [65-86-1] had no effect on the liver protein synthesis. The pyrimidine derivatives might affect enzyme synthesis by stimulating DNA-dependent RNA synthesis.

《Effect of pyrimidine derivatives on the incorporation of labeled amino acids into liver proteins》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Electric Literature of C5H6N2O2.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Application of 1194-22-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Near-infrared electrophotographic photoreceptor incorporating a hydroxy squaraine. Author is DiPaola-Baranyi, G.; Hsiao, C. K.; Kazmaier, P. M.; Burt, R.; Loutfy, R. O.; Martin, T. I..

The synthesis and xerog. evaluation of bis(4-dimethylamino-2-hydroxy-6-methylphenyl)squaraine (I) is described. Significant photosensitivity enhancement is observed upon addition of certain phenols during the synthesis of the squaraine. Neg. charged dual layer photoreceptor devices incorporating doped I are characterized by excellent xerog. properties such as low dark decay (<50 V/s), high white light and IR sensitivity (E1/2 ≃ 5 ergs/cm2 at 830 nm) and good short-term cycling stability. The effect of charge generator layer thickness, pigment loading and nature of the polymer binder are discussed. 《Near-infrared electrophotographic photoreceptor incorporating a hydroxy squaraine》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Application of 1194-22-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1194-22-5, is researched, Molecular C5H6N2O2, about The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives, the main research direction is DIHYDROXYPYRIMIDINES PMR; PYRIMIDINES PMR; HYDROXYPYRIMIDINES PMR.HPLC of Formula: 1194-22-5.

The proton N.M.R. spectra of 4,6-dihydroxypyrimidine and its 2- and 5-substituted derivatives have been compared with the spectra of their O- and N-methyl derivatives of fixed structures, corresponding to possible tautomeric forms. In a Me2SO medium the compounds exist predominantly in the oxohydroxy form. In aqueous solutions of 4,6-dihydroxypyrimidine and its N-methyl derivatives the bipolar-ionic form with delocalized charges probably predominates. 22 references.

《The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)HPLC of Formula: 1194-22-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Application of 1194-22-5.Jadhav, Pandurang M.; Sarangapani, Radhakrishnan; Patil, Rajendra S.; Pandey, Raj K. published the article 《Process Optimization, Product Profile Mapping, and Intensification of 1,1-Diamino-2,2-dinitroethylene》 about this compound( cas:1194-22-5 ) in Organic Process Research & Development. Keywords: process optimization product profile mapping intensification diaminodinitroethylene safety. Let’s learn more about this compound (cas:1194-22-5).

Industrialization of a chem. process needs an understanding of process chem., optimal process envelope, and the best choice of operation. 1,1-Diamino-2,2-dinitroethylene (FOX-7) is a new generation, and the highly insensitive compound finds application in high-energy formulations as well as preparation of novel high-energy compounds The present study highlights efforts made for establishing a continuous process for FOX-7. The intermediates of nitration of 2-methylpyrimidine-4,6-dione were isolated and characterized by spectroscopic tools. Reaction kinetics was also derived for the formation of intermediates. Product profiles of the reaction were evaluated on deriving expressions for various reactors. The simultaneous effect of heat and reaction was evaluated in a tubular reactor to obtain the runaway reaction condition. The effective reactor scheme was evaluated, designed, and experimented. Process intensification was carried out in a continuous set up comprising various contact patterns. The present study delivered a safe and productive method for FOX-7 processing.

《Process Optimization, Product Profile Mapping, and Intensification of 1,1-Diamino-2,2-dinitroethylene》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Application of 1194-22-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Methods for improvement of the process of synthesis of 1,1-diamino-2,2-dinitro-ethylene from 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methyl-2-methoxyimidazolidin-4,5-dione. Author is Kushtaev, Aleksandr A.; Yudin, Nikolai V.; Zbarskii, Vitol’d L.; Zhilin, Viktor F..

The nitration kinetics of 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methoxy-2-methyl-imidazolidone-4,5-dione was investigated. The hydrolysis kinetics of 2-(dinitro-methylene)-5,5- dinitro-pyrimidine-4,6(1 H,3H,5H)-dione and 2-(dinitro-methylene)-imidazolidone-4,5-dione has been studied. These results can be used for 1,1-diamino-2,2-dinitro-ethene technol. creation.

《Methods for improvement of the process of synthesis of 1,1-diamino-2,2-dinitro-ethylene from 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methyl-2-methoxyimidazolidin-4,5-dione》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Conference, Kratk. Tezisy – Vses. Soveshch. Probl. Mekh. Geteroliticheskikh Reakts. called Reaction of 4,6-dioxopyrimidines with sodium bisulfite, Author is Kheifets, G. M., which mentions a compound: 1194-22-5, SMILESS is CC1=NC(=CC(N1)=O)O, Molecular C5H6N2O2, Product Details of 1194-22-5.

4,6-Dioxopyrimidines form bisulfite adducts at the 2 position, but the equilibrium is shifted strongly toward the adduct only when no substituent is present at the 2 or 5 position. The rate of the forward reaction of the unsubstituted compound proceeds through a maximum as the pH is varied from 2 to 7. The rate-determining steps for the forward and reverse reactions of the different dioxopyrimidines are discussed.

Different reactions of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Product Details of 1194-22-5 require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Synthesis, structure, and properties of oligo-tridentate ligands; covalently assembled precursors of coordination arrays.Category: oxazolidine.

Oligo-tridentate ligands based on alternating pyridines and pyrimidines, e.g., I (R = H, Ph, 9-anthryl, R’ = H, Me, CH2Br) and II (R = H, Me, Ph), were synthesized by Stille-type carbon-carbon bond-forming reactions. The terpyridine-like sites are designed to coalign upon metal complexation, giving rise to organized and rigidly spaced metal ions. Peripheral functionalization of the basic bis-tridentate framework was explored. The heterocycles in the ligands are in an all-trans conformation about the interannular bonds as indicated by comparison of their 1H NMR spectra. An x-ray crystal structure anal. of the nonchiral tris-tridentate ligand II (R = H) reveals a helical structure in the solid state. The seven heterocycles form a helical structure with resulting overlap of the terminal pyridines. Their centroid-to-centroid distance is 4.523 Å with 38.8° between the planes. NMR investigations support a helical conformation in solution as well. Electrochem. and UV absorption measurements indicate that the LUMO resides on the pyrimidine moiety of the ligands.

Different reactions of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Category: oxazolidine require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem