Category: 1045894-43-6

Chiral-at-Iron Catalyst: Expanding the Chemical Space for Asymmetric Earth-Abundant Metal Catalysis was written by Hong, Yubiao; Jarrige, Lucie; Harms, Klaus; Meggers, Eric. And the article was included in Journal of the American Chemical Society on March 20,2019.Reference of 1045894-43-6 The following contents are mentioned in the article:

A new class of chiral iron catalysts is introduced that contains exclusively achiral ligands with the overall chirality being the result of a stereogenic iron center. Specifically, iron(II) is cis-coordinated to two N-(2-pyridyl)-substituted N-heterocyclic carbene (PyNHC) ligands in a bidentate fashion in addition to two monodentate acetonitriles, and the dicationic complex is complemented by two hexafluorophosphate ions. Depending on the helical twist of the PyNHC ligands, the metal center adopts either a Λ or Δ absolute configuration. Importantly, the two PyNHC ligands are constitutionally and configurationally inert, while the two acetonitriles are labile and allow asym. transition metal catalysis. This is demonstrated with an enantioselective Cannizzaro reaction (96% yield, 88% ee) and an asym. Nazarov cyclization (89% yield, >20:1 dr, 83% ee). This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Reference of 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Reference of 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis was written by Zheng, Yu; Tan, Yuqi; Harms, Klaus; Marsch, Michael; Riedel, Radostan; Zhang, Lilu; Meggers, Eric. And the article was included in Journal of the American Chemical Society on March 29,2017.HPLC of Formula: 1045894-43-6 The following contents are mentioned in the article:

A novel Ru catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centrochirality. The configurationally stable catalyst is demonstrated to catalyze the alkynylation of trifluoromethyl ketones with very high enantioselectivity (up to >99% ee) at low catalyst loadings (down to 0.2 mol%). This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6HPLC of Formula: 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.HPLC of Formula: 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Chiral-at-Ruthenium Catalyst with Sterically Demanding Furo[3,2-b]pyridine Ligands was written by Cui, Tianjiao; Qin, Jie; Harms, Klaus; Meggers, Eric. And the article was included in European Journal of Inorganic Chemistry in 2019.Product Details of 1045894-43-6 The following contents are mentioned in the article:

A sterically demanding derivative of a previously introduced chiral-at-metal ruthenium(II) catalyst scaffold, I (Λ-3, Δ-3; Ar = 2,4,6-Me3C6H2) is introduced. It is composed of two bidentate furo[3,2-b]pyridyl functionalized N-heterocyclic carbene ligands. Their cis-coordination generates helical chirality and a stereogenic ruthenium center. Two addnl. labile acetonitriles compose the catalytic site which is highly shielded by two 2-(tert-butyl)furo[3,2-b]pyridine moieties. The synthesis of the non-racemic ruthenium catalyst and its catalytic properties for the enantioselective alkynylation of 2,2,2-trifluoroacetophenone and pentafluorobenzaldehyde are reported and compared with sterically less demanding derivatives This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Product Details of 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Product Details of 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Chiral-at-Iron Catalyst for Highly Enantioselective and Diastereoselective Hetero-Diels-Alder Reaction was written by Hong, Yubiao; Cui, Tianjiao; Ivlev, Sergei; Xie, Xiulan; Meggers, Eric. And the article was included in Chemistry – A European Journal on June 10,2021.Formula: C12H15NO2 The following contents are mentioned in the article:

This study demonstrates that chiral-at-iron complexes, in which all coordinated ligands are achiral and the overall chirality the consequence of a stereogenic iron center, are capable of catalyzing asym. transformations with very high enantioselectivities. The catalyst is based on a previously reported design (J. Am. Chem. Soc. 2017, 139, 4322), in which iron(II) is surrounded by two configurationally inert achiral bidentate N-(2-pyridyl)-substituted N-heterocyclic carbenes in a C2-sym. fashion and complemented by two labile acetonitriles. By replacing mesityl with more bulky 2,6-diisopropylphenyl substituents at the NHC ligands, the steric hindrance at the catalytic site was increased, thereby providing a markedly improved asym. induction. The new chiral-at-iron catalyst was applied to the inverse electron demand hetero-Diels-Alder reaction between β,γ-unsaturated α-ketoester and enol ethers provide 3,4-dihydro-2H-pyrans in high yields with excellent diastereoselectivities (up to 99 : 1 dr) and excellent enantioselectivities (up to 98% ee). Other electron rich dienophiles are also suitable as demonstrated for a reaction with a vinyl azide. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Formula: C12H15NO2).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Formula: C12H15NO2

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Chiral-Auxiliary-Mediated Asymmetric Synthesis of Tris-Heteroleptic Ruthenium Polypyridyl Complexes was written by Gong, Lei; Mulcahy, Seann P.; Harms, Klaus; Meggers, Eric. And the article was included in Journal of the American Chemical Society on July 22,2009.Related Products of 1045894-43-6 The following contents are mentioned in the article:

A strategy for the asym. synthesis of chiral-at-metal [Ru(pp)(pp’)(pp”)]+ complexes (Hpp = isopropyl-2-(2′-hydroxyphenyl)oxazoline, pp’ and pp” = achiral 2,2′-bipyridine, 5,5′-dimethyl- and 4,4′-di-tert-butyl-2,2′-bipyridine), is reported. The method employs isopropyl-2-(2′-hydroxyphenyl)oxazolines as chiral auxiliaries, which serve in their deprotonated forms as strong bidentate ligands that provide excellent asym. induction in the coordination chem. and, importantly, can afterward become substituted with complete retention of configuration in the presence of acid. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Related Products of 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Related Products of 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

2-[(4R)-4,5-dihydro-4-R-2-oxazolyl]phenyl diphenylphosphonate, and synthesis method and application thereof was written by Luo, Mei. And the patent was published on July 20,2011.SDS of cas: 1045894-43-6 The following contents are mentioned in the patent:

Title compound as shown formula I is synthesized by allowing to react 2-cyanophenol with d-amino alc. in O2-free anhydrous chlorobenzene in the presence of ZnCl2 under refluxing for 24 h to obtain 2-[(4R)-4,5-dihydro-4-R-2-oxazolyl]phenol, and then allowing to react with diphenylphosphonyl chloride in O2-free anhydrous toluene-triethylamine under refluxing for 24 h, wherein R = -CH2CH(CH3)2, -CH(CH3)2, Ph, or -CH2Ph. The compound can be used as chiral catalyst and shows good catalytic activity and high enantioselectivity during asym. synthesis of 2-methylbenzaldehyde. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6SDS of cas: 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.SDS of cas: 1045894-43-6

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Method for synthesis of diphenylphosphinic acid was written by Luo, Mei. And the patent was published on February 15,2012.COA of Formula: C12H15NO2 The following contents are mentioned in the patent:

The title method comprises preparing 2-[(4R/S)-4,5-dihydro-4-R-2-oxazolinyl]phenol or 2-[(4R/S)-4,5-dihydro-4-R-2-oxazolinyl]aniline, reacting with diphenylphosphinyl chloride in toluene in the presence of triethylamine for 2 days, filtering, evaporating, carrying out chromatog. with petroleum ether-dichloromethane (1:9) as eluent and volatilizing to obtain diphenylphosphonic acid crystal. The yield is about 5%. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6COA of Formula: C12H15NO2).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.COA of Formula: C12H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Preparation method of chiral aromatic amine compounds by alkylation and rearrangement was written by Guo, Chang; Chang, Xihao; Zhang, Qinglin. And the patent was published on March 20,2018.HPLC of Formula: 1045894-43-6 The following contents are mentioned in the patent:

The invention relates to the preparation method of chiral aromatic amine compounds, i.e., I and II, by alkylation and rearrangement. The prepared chiral aromatic amine compounds have high optical purity (ee value above 99%), has wide application in field of bioactive materials, chiral ligands and chiral catalysts, and can be derived for the further preparation of racemized or chiral aromatic imide ligands as the catalyst for asym. catalytic reactions. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6HPLC of Formula: 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.HPLC of Formula: 1045894-43-6

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem