Can You Really Do Chemisty Experiments About (R)-4-Benzyl-2-oxazolidinone

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Iron-catalyzed amidation of alkynyl bromides: A facile route for the preparation of ynamides

(Chemical Equation Presented) A facile route to obtain ynamides in high yields was described. The products were achieved through the iron-catalyzed C-N coupling reaction of amides with alkynyl bromides in the presence of 20 mol % of N,N?-dimethylethane-1,2-diamine (DMEDA).

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2097NO – PubChem

 

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MIGRASTATIN ANALOGS IN THE TREATMENT OF CANCER

In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, ,-R,, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.

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Oxazolidine – Wikipedia,
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Can You Really Do Chemisty Experiments About (R)-4-Benzyl-2-oxazolidinone

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PROCESS FOR PREPARING POSACONAZOLE AND INTERMEDIATES THEREOF

The present invention relates to an industrially advantageous process for the preparation of tetrahydrofuran antifungals preferably posaconazole of formula I. The present invention further relates to improved processes for preparing key and novel intermediates useful in the preparation of posaconazole. The present invention further relates to improved processes for preparing the compound of formula II, a key intermediate in the preparation of posaconazole.

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IDO inhibitors (by machine translation)

The present invention relates to a compound of formula I or a pharmaceutically acceptable salt, solvate, hydrate, active metabolite, polymorph, ester, isotopic compound, stereoisomer or prodrug, a pharmaceutical composition comprising a compound of formula I and its use as IDO inhibitor for the preparation of a medicament for preventing or treating cancer, viral infection, depression, cataract, organ transplantation rejection, or autoimmune disease thereof. (by machine translation)

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Fluoroalkenes as peptide isosteres: Ground state analog inhibitors of thermolysin

Tripeptide analogs of the form Cbz-GlyPsi[(Z/-CF=CH]LeuXaa (1, Xaa = Gly, Ala, Leu, Phe, and NH2) were synthesized to assess the ability of the fluoroalkene moiety to mimic a peptide linkage. These compounds are modest inhibitors of the zinc endopeptidase thermolysin (0.19 mM < K(i) < 1.8 mM); the K(i) values correlate strongly with the K(m) values, but not K(m)/k(cat), for hydrolysis of the corresponding peptides. The correlation indicates that these inhibitors bind as ground state analogs and represent the first direct assessment of the fluoroalkene unit as a peptide surrogate. One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Formula: C10H11NO2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 102029-44-7

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Discovery of (R)-4-Benzyl-2-oxazolidinone

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Palladium-catalyzed cross-coupling of fluorinated vinyl chlorides with terminal alkynes: A general protocol to fluorinated enynes

An efficient and cost-effective method for the preparation of fluorinated conjugated enynes was described. The method was compatible with a variety of functional groups such as chloride, amine, cyano and ester group. The method could also be extended to the coupling of (R,Z)-3-(2-chloro-1,2-difluorovinyl)- 4-alkyloxazolidin-2-one (3) with moderate yields. An efficient and cost-effective method for the preparation of fluorinated conjugated enynes was described. The method was compatible with a variety of functional groups such as chloride, amine, cyano and ester group. The method could also be extended to the coupling of (R,Z)-3-(2-chloro-1,2-difluorovinyl)-4-alkyloxazolidin-2-one (3) with moderate yields. Copyright

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Oxazolidine – Wikipedia,
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Facile formation of N-acyl-oxazolidinone derivatives using acid fluorides

A mild method is presented for the formation of N-acylated oxazolidinones that employs acid fluorides and mild bases, such as iPr 2NEt and NEt3. Optimized reaction conditions for two types of substrates have been developed utilizing either the oxazolidinone itself or the corresponding in situ generated O-silyloxazolidinones resulting in the formation of the desired N-acylated products in high yields of up to 98%.

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Discovery of (R)-4-Benzyl-2-oxazolidinone

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Chiral electrophilic ‘glycinal’ equivalents. New synthons for optically active alpha-amino acids and 4-substituted 2-oxazolidinones

The thermal reaction of 3-[(1S)-2-alkoxy-1-apocamphanecarbonyl]-2-oxazolones (21a-c) with dialkyl azodicarboxylates (9) results in exclusive formation of [4 + 2] type cycloadducts (22 and 23) with moderate levels of diastereofacial selection (up to 72% d.e.). The diastereomers thus obtained were readily purified and subsequent treatment with acidic methanol followed by removal of the auxiliary with LiBH4/MeOH (1:2) gave optically pure 4-methoxy-5-hydrazino-2-oxazolidinones (26 and 27), which serve as alpha-aminoaldehyde templates useful for the synthesis of a wide variety of optically active alpha-amino acids as well as 4-alkyl and 4-aryl-2-oxazolidinones.

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Archives for Chemistry Experiments of (R)-4-Benzyl-2-oxazolidinone

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Oxazolidinone penetration enhancing compounds

Compositions for carrying physiologically active agents through body membranes having the structural formula I: STR1 where: R=H, Alkyl group containing from 1-18 carbon atoms, cycloalkyl, aryl, aralkyl, alkoxy, hydroxyalkyl, alkoyloxyalkyl, acyloxyalkyl and alkoxyalkyl; X=O and NR1, where R1 is selected from H, alkyl, aralkyl acyl group containing from 1-18 carbon atoms, cycloalkyl, hydroxyalkyl, alkoyloxyalkyl acyloxyalkyl and alkoxyalkyl; Y=O and NR2, where R2 is selected from H, alkyl, aralkyl, cycloalkyl, acyl group containing from 1-18 carbon atoms, hydroxyalkyl, alkoyloxyalkyl, acyloxyalkyl and alkoxyalkyl; m=2-4; and n=0-4, are disclosed.

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Diastereoselective synthesis of fused lactone-pyrrolidinones; Application to a formal synthesis of (-)-salinosporamide a

A mild, diastereoselective synthesis of fused lactone-pyrrolidinones using an oxidative radical cyclization is reported. The methodology is demonstrated in a formal synthesis of (-)-salinosporamide A.

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Oxazolidine – Wikipedia,
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