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ASYMMETRIC TOTAL SYNTHESES OF (+)- AND (-)-PULO’UPONE

Asymmetric total syntheses of both enantiomers of marine mollusk metabolite pulo’upone 1 have been achieved by Evans’ asymmetric Diels-Alder reaction.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2038NO – PubChem

 

Brief introduction of (R)-4-Benzyl-2-oxazolidinone

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A New Electrophilic Alaninol Synthon. A General Route to Oxazolidinones of D or (R)-2-Amino Alcohols from L-Serine

A new electrophilic alaninol synthon, (S)-4-(4′-tolylsulfonyloxymethyl)oxazolidin-2-one, derived from serine, undergoes nucleophilic displacements with Gilman cuprates and/or Grignard/CuX reagents in high yields to provide (R)-4-substituted oxazolidinones.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2019NO – PubChem

 

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Asymmetric Total Synthesis of (+)-(3E)-Pinnatifidenyne via Abnormally Regioselective Pd(0)-Catalyzed Endocyclization

The asymmetric total synthesis of the marine natural product (+)-(3E)-pinnatifidenyne was accomplished. The key features of the synthesis involve the construction of an eight-membered cyclic ether by the abnormally regioselective Pd(0)-catalyzed cyclization, the installation of a double bond in the oxocene skeleton by sequential in situ deconjugative isomerization, and the efficient introduction of the crucial chloride mediated by the substrate-controlled diastereoselective reduction.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1884NO – PubChem

 

Awesome Chemistry Experiments For 102029-44-7

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A preparation N-substituted oxazole alkone chiral method of ligand (by machine translation)

The invention relates to preparing N-substituted oxazole alkone chiral biligand method technical field. N of the invention-substituted oxazole alkone chiral biligand the preparation method of the compound of the following formula with A R 1-COCl in the alkaline reagent tertiary butyl alcohol potassium, sodium methoxide or NaNH 2 to obtain the target product reaction under the effect of (1): wherein R 1 represents the carbon atom number is less than or equal to 7 alkyl; R 2 is phenyl, benzyl or isopropyl. This invention use tert butoxide, potassium and the like commonly used instead of the prior art composite material, hexa reagent such as two silicon base amidogen lithium reaction at normal temperature, and shorten the reaction time, the reaction is completed after the completion of feeding, after the subsequent processing operation can be carried out, the dynamic cost saving; not in post-treatment process in the emit a large amount of gas, the safety is high; to obtain a target compound of high-yield, high-purity, suitable for industrial production. (by machine translation)

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1696NO – PubChem

 

The Absolute Best Science Experiment for (R)-4-Benzyl-2-oxazolidinone

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 102029-44-7, and how the biochemistry of the body works.Quality Control of (R)-4-Benzyl-2-oxazolidinone

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 102029-44-7, name is (R)-4-Benzyl-2-oxazolidinone, introducing its new discovery. Quality Control of (R)-4-Benzyl-2-oxazolidinone

PHARMACEUTICAL COMPOUNDS

The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1605NO – PubChem

 

More research is needed about (R)-4-Benzyl-2-oxazolidinone

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SYNUCLEINOPATHY THERAPEUTIC MEDICATION

This invention provides a pharmaceutical composition for treating or preventing synucleinopathy comprising a compound represented by formula (I), or a pharmaceutically acceptable salt thereof.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1591NO – PubChem

 

Archives for Chemistry Experiments of 102029-44-7

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of (R)-4-Benzyl-2-oxazolidinone, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2

A AR – 13324 preparation method (by machine translation)

The invention relates to a AR – 13324 preparation method, this invention utilizes the chiral ligand chiral inducing synthetic AR – 13324, chiral HPLC method with the prior of the SFC or compared, using chemical synthesis method to produce AR – 13324 has simple operation, synthetic condition is simple, low cost, high purity was chiral monomer, and high yield. (by machine translation)

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1630NO – PubChem

 

Properties and Exciting Facts About (R)-4-Benzyl-2-oxazolidinone

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Total Synthesis of Norsampsones A and B, Garcinielliptones N and O, and Hyperscabrin A

The asymmetric total synthesis of five decarbonyl polycyclic polyprenylated acylphloroglucinols norsampsnes A (3) and B (4), garcinielliptones O (5) and N (6), and hyperscabrin A (7) is described. The synthesis to construct the core substituted cyclohexanone ring of these natural products was achieved by a key Dieckmann condensation. The chirality of the molecules was introduced by the stereoselective alkylation with Evans’ oxazolidinones. The synthesis could be run on grams scale, and the Dieckmann condensation was investigated through the DFT calculations to help improve the yield of garcinielliptone O (5). Determination of the absolute configuration of garcinielliptones O (5) and N (6) was also achieved.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2107NO – PubChem

 

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Transition-metal-catalyzed synthesis of 1,3-diynes and ynamides from 2-bromo-1-iodoalkenes

Diynes and ynamides are important products in chemical synthesis. An efficient palladium-catalyzed homocoupling reaction of 2-bromo-1-iodoalkenes to give 1,3-diynes has been developed. The reactions are conducted under convenient conditions and provide products in moderate to excellent yields. Moreover, ynamides were synthesized from 2-bromo-1-iodoalkenes and carbamates, and it is noteworthy that this reaction is catalyzed by nanoparticulate copper(I) oxide to give ynamides in high yields.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2082NO – PubChem

 

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MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF

A compound and a method thereof are provided. The compound of the invention has formula I shown below. Each variable in formula I and manufacturing method are defined in the specification. The invention also provides a method for treating organ dysfunction.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1628NO – PubChem