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Formula: C10H11NO2, Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials.102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2. In a Article，once mentioned of 102029-44-7

Methanethiosulfonate reagents may be used to introduce virtually unlimited structural modifications in enzymes via reaction with the thiol group of cysteine. The covalent coupling of enantiomerically pure (R) and (S) chiral auxiliary methanethiosulfonate ligands to cysteine mutants of subtilisin Bacillus lentus induces spectacular changes in catalytic activity between diastereomeric enzymes. Amidase and esterase kinetic assays using a low substrate approximation were used to establish k(cat)/K(M) values for the chemically modified mutants, and up to 3-fold differences in activity were found between diastereomeric enzymes. Changing the length of the carbon chain linking the phenyl or benzyl oxazolidinone ligand to the mutant N62C by a methylene unit reverses which diastereomeric enzyme is more active. Similarly, changing from a phenyl to benzyl oxazolidinone ligand at S166C reverses which diastereomeric enzyme is more active. Chiral modifications at S166C and L217C give CMMs having both high esterase k(cat)/K(M)’s and high esterase to amidase ratios with large differences between diastereomeric enzymes. Copyright (C) 2000 Elsevier Science Ltd.

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The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

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Chemistry is traditionally divided into organic and inorganic chemistry. Reference of 102029-44-7, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 102029-44-7

Provided are compounds of Formular (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds thereof, and use of these compounds in preparing drugs for inhibiting ROCK.

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alpha-Methylacyl-CoA racemase (AMACR) is an important enzyme for the metabolism of branched-chain lipids and drugs. The enzyme is over-expressed in prostate and other cancers. AMACR 1A, the major splice variant, was purified from recombinant E. coli cells as a His-tag protein. Purified enzyme catalysed chiral inversion of both S- and R-2-methyldecanoyl-CoA, with an equilibrium constant of 1.09 ± 0.14 (2S/2R). Reactions with 2H-labelled substrate showed that loss of the alpha-proton was a prerequisite for chiral inversion. Reactions conducted in 2H2O indicated that reprotonation was not stereospecific. These results are the first mechanistic study on any recombinant mammalian alpha-methylacyl-CoA racemase. The Royal Society of Chemistry 2009.

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Chemistry can be defined as the study of matter and the changes it undergoes. Safety of (R)-4-Benzyl-2-oxazolidinone. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.Safety of (R)-4-Benzyl-2-oxazolidinone, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2, introducing its new discovery.

The enantiomers of 8-<<(4-chlorophenyl)sulfonyl>amino>-4-(3-pyridinylpropyl)octanoic acid (1) and its pyridinyl ether analog (2) were synthesized using the highly diastereoselective method of alkylation of acyloxazolidinone.These enantiomerically pure compounds were compared with the corresponding racemic compounds 1 and 2 for their in vitro activity.Compounds 1, 1R, and 1S and 2, 2S, and 2R were equipotent as thromboxane receptor antagonists (TxRAS) and thromboxane synthase inhibitors (TxSIs) (IC50 = 2-30 nM).Upon oral administration to guinea pigs, the enantiomers inhibited the ex vivo U 46619-induced platelet aggregation with potency similar to that of the corresponding racemic compound.This indicates that the enantiomers have pharmacologic profile and bioavailability similar to that of tha corresponding racemic compound.

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Chemistry can be defined as the study of matter and the changes it undergoes. Related Products of 102029-44-7. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.Related Products of 102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2, introducing its new discovery.

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This paper describes synthetic studies towards carolacton, a highly potent antibiotic against dental caries and endocarditis related bacterium Streptococcus mutans. The synthesis of the 12-membered lactone with a diversely functionalized keto acid side chain was accomplished by utilizing a blend of chiral pool and aldol strategies. Carbon chain C1-C8 was derived by utilizing Paterson aldol methodology and a Corey-Fuchs reaction. The C9-C19 chain was prepared by means of iterative Evans asymmetric alkylations and an E-selective cross-metathesis reaction. Georg Thieme Verlag Stuttgart New York.

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A novel and efficient fast synthesis of 3-amino isocoumarins in good to excellent yields is reported. These interesting scaffolds can be obtained either in a single step from readily available ynamides or in a two-step sequence from the corresponding alkynyl bromide after C-N cross-coupling. This protocol, which only requires a Br°nsted or Lewis acid as a promoter, offers an alternative approach toward synthesizing 3-substituted isocoumarins under smooth and fast conditions.

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The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).

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Formula: C10H11NO2, Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. In a article, 102029-44-7, molcular formula is C10H11NO2, introducing its new discovery.

Asymmetric total synthesis of emericellamide B (9.4%, 17 longest linear steps) is detailed in this report. In this synthetic route, the highly methylated (2R,3R,4S,6S)-3-hydroxy-2,4,6-trimethyldodecanoic acid (HTMD) unit was effectively prepared through the asymmetric methylation, Wittig and Horner-Wadsworth-Emmons reaction. Moreover, pentafluorophenyl diphenylphophinate (FDPP) proved to be an effective condensation reagent for the macrolactamization between C14 and C18.

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