Can You Really Do Chemisty Experiments About 99395-88-7

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2. In an article, author is Konov, Konstantin B.,once mentioned of 99395-88-7, Safety of (S)-4-Phenyloxazolidin-2-one.

Low-Temperature Molecular Motions in Lipid Bilayers in the Presence of Sugars: Insights into Cryoprotective Mechanisms

Sugars and sugar alcohols can stabilize biological systems under extreme conditions of desiccation and freezing. Phospholipid bilayers solvated by aqueous solutions of sucrose, trehalose, and sorbitol at concentrations of 0.2 and 1 M and containing incorporated spin-labeled stearic acids were studied by electron spin echo (ESE) spectroscopy, a pulsed version of electron paramagnetic resonance (EPR). The phospholipids were 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and the stearic acids were labeled with nitroxide 4,4-dimethyl-oxazolidine-1-oxyl (DOXYL) attached rigidly at either the 5th or 16th carbon positions. The ratio of the echo time traces for the two field positions in the EPR spectrum possessing the largest and smallest anisotropies gave the anisotropic contribution to the echo decay, which obeys exponential time dependence with good accuracy. At low temperatures, the anisotropic contribution is induced by stochastic (or diffusive) orientational vibrations of the molecule as a whole (i.e., stochastic molecular librations), with the exponential decay rate W-anis proportional to tau(c), where is the mean angular amplitude of the motion and tau(c) is the correlation time. In all cases, it was found that W-anis begins to increase sharply above 170200 K, which was ascribed to the dynamical transition known for biological systems at these temperatures. For hydration by the sucrose and trehalose solutions, W-anis was found to increase noticeably also above similar to 120 K, which was explained by bilayer expansion due to direct bonding of sugar molecules to the bilayer surface. The W-anis temperature dependencies were found to be close to those obtained for the simple systems of the nitroxide spin probe TEMPONE in aqueous sorbitol and sugar 1 M solutions. This correlation suggests a possible mechanism of cryoprotective action of sorbitol and sugars due to the similarity of low-temperature motions in the membrane and in the cryoprotectant-containing surrounding liquid.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem