Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Evans, David A. and a compound is mentioned, 145589-03-3, (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, introducing its new discovery. 145589-03-3
The Asymmetric Synthesis of alpha-Amino and alpha-Hydrazino Acid Derivatives via The Stereoselective Amination of Chiral Enolates with Azodicarboxylate Esters.
The utility of azodicarboxylate esters as (+)NH2 and (+)NH-NH2 synthons in highly diastereoselective reactions with chiral carboximide-derived enolates has been demonstrated.The lithium enolates derived from 4-substituted N-acyl 2-oxazolidinones were found to react with di-tert-butyl azodicarboxylate (DBAD) to afford the derived 2-hydrazido carboxylic acid derivetives in yields in excess of 90 percent.The diastereoselectivities of these reactions ranged from 97percent to greater than 99percent.The subsequent transformation of these adducts to both alpha-hydrazino and alpha-amino acids in enantiomeric purities in excess of 99percent is described.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 196603-96-0!, 145589-03-3
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2588NO – PubChem