Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Modeling & simulation of micro reactor with nitration of 2-methyl-4,6-dihydroxy-pyrimidine. Author is Mandal, Alok Kumar; Pandey, Raj Kishore; Asthana, Shri Nandan; Kulkarni, Amol; Kulkarni, Bhaskar Dattatraya.
Nitration of 2-methyl-4,6-dihydroxypyrimidine (MDP) using concentrated sulfuric acid and nitric acid as nitrating mixture is a highly exothermic and hazardous reaction. Conducting such reaction in a batch reactor follow an unsteady state and its trajectory depends on various important parameters such as initial reactor temperature, initial composition of reaction mass, temperature of circulating coolant, etc. However, over all productivity, process control, and safety of the batch process is highly restricted due to lower surface to volume ratio. In the present work, an effort was made to over come the limitations of batch reactor by using the novel micro reactor device. Micro reactor is having extremely high surface to volume ratio, which was explored to carry out nitration of MDP both numerically as well as exptl. and the results were compared with conventional batch reactor. The micro reaction system was modeled using two dimensional (2-D) heat flow and mass transfer equations. The kinetic rate equation for nitration of MDP has evaluated exptl. by differential method which is used in modeling of the micro reactor. The numerical results from the 2-D model for conversion and temperature profile along the length and radius of micro reactor were compared with corresponding results obtained from batch reactor. In order to validate the model, several experiments were conducted in micro reactor set-up with the variation of flow rate, residence time, concentration, temperature, etc. The exptl. results from micro reactor revealed that nitration of MDP takes place even at much lower concentration and lower residence time with better control of temperature profile. Also, the reaction takes place in laminar region compared to turbulent region in corresponding batch reactor setup.
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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem