On October 28, 2004, Burke, Martin D.; Berger, Eric M.; Kwon, Ohyun; Park, Seung Bum; Schreiber, Stuart L. published a patent.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the patent was Generation of skeletal diversity within a combinatorial library. And the patent contained the following:
The present invention provides a method of synthesizing a library of chem. compounds with skeletal diversity. Two approaches are used to create skeletal diversity within a library of chem. compounds: (1) the “”branching pathways”” (or reagent-based) approach; and (2) the “”folding pathways”” (or substrate-based) approach. Upon exposure to certain reaction conditions the members of the library undergo unique transformations into a diverse collection of mol. skeletons, which can be functionalized and derivatized further to generate a large collection of unique, natural product-like compounds A furan-based library synthesized using the folding pathways approach is provided, and a polycyclic library created using the branching pathways approach is also provided. The invention also provides materials, reagents, intermediates, and kits useful in the practice of the inventive method as well as method for screening the inventive compounds The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one
The Article related to oxazolidinone combinatorial library stereoselective preparation solid phase synthesis, split pool synthesis skeletal diversity combinatorial chem oxazolidinone preparation, combinatorial matrix mol skeleton furan derivatization, skeletal diversity branched diels alder polycyclic combinatorial library and other aspects.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem