On September 16, 2016, Brun, Elodie; Bellosta, Veronique; Cossy, Janine published an article.Electric Literature of 168297-86-7 The title of the article was Synthesis of the Acyclic Carbon Skeleton of Filipin III. And the article contained the following:
The synthesis of the carbon skeleton I of filipin III (II), a polyenic macrolactone possessing 11 stereogenic centers, has been achieved using a convergent strategy with a longest linear sequence of 19 steps starting from hexanal. The construction of the polyene has been realized by using two successive Heck couplings as the key steps. The control of the stereogenic centers of the polyol fragment has been performed by utilizing an Evans aldolization, a 1,3-syn aldolization, enantio- and diastereoselective allylations, an hemiacetalization/oxa-Michael sequence and a 1,3-syn reduction The polyol and polyenic fragments have been coupled using a 1,5-anti diastereoselective aldolization followed by a 1,3-anti reduction The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Electric Literature of 168297-86-7
The Article related to filipin iii acyclic carbon skeleton preparation convergent strategy, hexanal synthon filipin iii acyclic carbon skeleton, successive heck coupling reaction filipin iii synthesis, aldolization evans syn anti filipin iii synthesis, enantioselective allylation filipin iii synthesis, diastereoselective allylation filipin iii synthesis and other aspects.Electric Literature of 168297-86-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem