Application of 102029-44-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 102029-44-7, molcular formula is C10H11NO2, introducing its new discovery.
The natural product colletoic acid (CA) is a selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which primarily converts cortisone to the active glucocorticoid (GC) cortisol. Here, CA’s mode of action and its potential as a chemical tool to study intracellular GC signaling in adipogenesis are disclosed. 11beta-HSD1 biochemical studies of CA indicated that its functional groups at C-1, C-4, and C-9 were important for enzymatic activity; an X-ray crystal structure of 11beta-HSD1 bound to CA at 2.6 A resolution revealed the nature of those interactions, namely, a close-fitting and favorable interactions between the constrained CA spirocycle and the catalytic triad of 11beta-HSD1. Structure-activity relationship studies culminated in the development of a superior CA analogue with improved target engagement. Furthermore, we demonstrate that CA selectively inhibits preadipocyte differentiation through 11beta-HSD1 inhibition, suppressing other relevant key drivers of adipogenesis (i.e., PPARgamma, PGC-1alpha), presumably by negatively modulating the glucocorticoid signaling pathway. The combined findings provide an in-depth evaluation of the mode of action of CA and its potential as a tool compound to study adipose tissue and its implications in metabolic syndrome.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 102029-44-7 is helpful to your research. Application of 102029-44-7
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1910NO – PubChem