99395-88-7, (S)-4-Phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In three 500ml flask, was added ( s) -4- phenyl-2-oxazolone 20g (0.122mol, 1eq.) And dichloromethane 200ml, cooled to between 0 ~ 10 , was added chlorotrimethylsilane 15.86g (0.146mol, 1.2eq.), kept under stirring at 0 ~ 10 30 minutes, a solution of diisopropylethylamine 39.30g (0.305mol, 2.50eq.), was added dropwise in the temperature control of the material during 0 ~ between 10 , after completion of the dropwiseaddition, stirring was continued for 2 hours at 0 ~ 10 until (s) -4- phenyl-2-oxazolone starting material by TLC the reaction was complete (monitored by TLC conditions: petroleum ether / ethyl acetate acetate = 2/1).acryloyl chloride WAS the then added 15.46 g (0.171 mol, 1.4 eq.), at The temperature at The Control of Material’s at The Addition During the BETWEEN 0 ~ 10 deg.] C, the After Addition at The Complete WAS, WAS added of 1.6 g of anhydrous Tetrabutylammonium fluoride (of TBAF, 6.1 mmol, 0.05 eq.), at The Reaction WAS AT Stirred Room temperature for 2 hours.the After Completion of at The Reaction, Reaction Solution at The WAS Poured INTO ICE 200ml of Water, and Stirred AT Room temperature for 30 minutes, at The Organic Phase WAS Separated, at The Organic Phase WAS Washed the with 10% (wt) WAS Washed the with Sodium bicarbonate Solution, at The Organic Phase WAS Separated, Evaporated to Dryness to give at The crude Product the After at The Organic Phase.Isopropyl alcohol WAS added to at The crude Product 100ml, Stirred AT 25 Suction Filtration hours to 2 deg.] C to give A White Solid Powder, and dried to give Compound at The Product 24.6 g, a yield 93%.1, 99395-88-7
The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Jiangsu Hengsheng Pharmaceutical Co., Ltd; Wang, Xilin; Ding, Zunliang; Wu, Huafeng; Wang, Zhe; Chen, Zhikuan; (9 pag.)CN105541742; (2016); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem