99395-88-7, (S)-4-Phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To (S)-4-phenyloxazolidin-2-one 2(9.88 g, 60 mmol) in THF (150 mL) at – 78 oC, was added n-butyllithium (37.7 mL, 1.6 M inhexanes, 60 mmol) over a period of 30 min.THF (50mL) was added to the resultant thick suspension and the reactionmixture allowed warming up to facilitate stirring. trans-Cinnamoylchloride 3(11.5 g, 69 mmol) in THF (30 mL) was added drop wise. The reaction was stirred at room temperatureovernight. The reaction mixture wasquenched with a saturated NH4Cl (50 mL) and stirred for 0.5 hr. The solvent was removed in vacuo, the residuewas dissolved in ethyl acetate, washed with water (300 mL), 5% NaHCO3(200 mL) and brine (100 mL) and dried over Na2SO4. The solvent was removed with addition ofhexane to give a white microcrystalline (14.6 g, 83%) of the product 4 as a white solid: mp 170 C; Rf = 0.43 (20% EtOAc in hexanes);[alpha]D20 = +11.0o (c 0.81);1 HRMS(C18H15NO3): calcd294.1124, found 294.1095 [M+H]+; IR (neat) numax 3290.49,1757.13, 1678.11, 1204.13 cm-1; UV (nm) 220, 300; 1H NMR(CDCl3) delta 7.92 (d, J = 24 Hz, 1H), 7.81(d, J = 24 Hz, 1H), 7.62 (m, 2H), 7.42 (m,8H), 5.59 (dd, J = 9, 2.1 Hz, 1H),6.36 (dd, J = 8.7, 3.8 Hz, 1H), 4.77 (t,J = 8.5 Hz, 1H), 4.35 (dd, J = 8.7, 3.8 Hz, 1H); 13C NMR(CDCl3) delta 166.9, 164.8, 146.7, 139.1, 134.5, 130.7, 129.2, 128.7,128.6, 126.0, 116.9, 70.0, 57.9., 99395-88-7
The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Maxwell, David S.; Sun, Duoli; Peng, Zhenghong; Martin, Diana V.; Bhanu Prasad, Basvoju A.; Bornmann, William G.; Tetrahedron Letters; vol. 54; 43; (2013); p. 5799 – 5801;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem