95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
95530-58-8, To a solution of hex-5-enoic acid (11.24 g, 87.0 mmol), (4R)-4-isopropyl-1, 3-oxazolidin- 2-one (12.91 g, 113. 1 mmol) and DMAP (1. 06 g, 8.70 mmol) in CH2CI2, was added DCC (23.33 g, 113. 1 mmol) at 0 C and the mixture was stirred at 0 C for 15 min. Then the mixture was stirred at room temperature overnight and was filtered through a pad of celite and the filtrate was washed with sat. NaHCO3aq. The organic layer was dried over Na2SO4, filtered and evaporated. The crude product was purified by silica gel column chromatography (hexane-AcOEt 20: 1-10: 1) to give the titled compound (16.60 g, 73.7 mmol). 1H NMR (CDCI3) 6 : 5.90-5. 70 (m, 1H), 5.10-4. 95 (m, 2H), 4.50-4. 42 (m, 1H), 4.35-4. 15 (m, 2H), 3.10-2. 80 (m, 2H), 2.46-2. 30 (m, 1H), 2.20-2. 08 (m, 2H), 1.90-1. 68 (m, 2H), 0.92 (d, J = 7.1 Hz, 3H), 0.88 (d, J= 6.9 Hz, 3H) ppm
The synthetic route of 95530-58-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER JAPAN, INC.; PFIZER INC.; WO2005/80317; (2005); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem