95530-58-8,95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The R type EvansAuxiliary base addedTo 250 ml of dry reaction flask,70 ml of anhydrous THF dissolved,Cooled to -78 C,And then slowly adding n-BuLi (18.5 ml, 46.3 mmol)After 30 min reaction,(E) -2-methyl-2-butenoyl chloride (5.0 g, 42.5 mmol) was added and reacted for 30 min. The temperature was raised to 0 C and the reaction was continued for 15 min.20ml saturated ammonium chloride quenching reaction, separationThe organic phase was extracted with ethyl acetate (20 ml x 3). The organic phases were combined, washed with saturated brine (40 ml), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure.The residue was subjected to column chromatography (elution conditions, petroleum ether: ethyl acetate = 10: 1) to give the product as a white solid, 7.7 g, 94% yield;
The synthetic route of 95530-58-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Fudan University; Lei Xinsheng; Lin Guoqiang; Zhao Qun; Xu Qianqian; Shan Guangsheng; (20 pag.)CN104418707; (2017); B;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem