875444-08-9,875444-08-9, (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4- methyloxazolidin-2-one (46g, 147mol), obtained in step 2, in DMF (150ml) was dropwise added NaHMDS (sodium hexamethyldisilazide) (176 ml, 176 mol) at -40C. The reaction mixture was stirred for 30 min, and slowly added with drops of a dilution of 2-chloro-5- (trifluoromethyl)pyridin-3-yl-methane chloride, obtained in step 1 , in DMF (30ml). The resulting reaction mixture was heated to room temperature, stirred for 3 hrs, diluted with ethyl acetate (200 ml), and added with water (500 ml) to terminate the reaction. The organic layer thus formed was withdrawn, washed with water (2.5 I), and filtered through silica-selite pad at a reduced pressure to afford the title compound (60g, 67%). 1 H NMR (400MHz, CDCI3) . 8.64 (s, 1 H), 8.01 (s, 1 H), 7.90 (s, 1 H), 7.82 (s, 2H), 5.76 (d, J = 8.0Hz, 1 H), 4.84 (d, J = 16.0Hz, 1 H), 4.47 (d, J = 16.4Hz, 1 H), 4.22 (m, 1 H), 083 (d, 3H).
The synthetic route of 875444-08-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DONG-A ST CO.,LTD; PARK, Jang Hyun; SONG, Seung Hyun; CHUNG, Han Kook; KIM, Heung Jae; LEE, Ji Hye; JANG, Byeong Jun; KIM, Eun Jung; JUNG, Hae Hum; RYU, Chae Lim; HWANG, Jae-Sung; LEE, Hyung Ki; KANG, Kyung Koo; KIM, Soon Hoe; WO2014/157994; (2014); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem