875444-08-9, (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3′-(2-(Bromomethyl)-4,4-dicyclohex-l-enyl)-3,5-difiuoro-4′-methoxy-4-(methoxy methoxy)biphenyl, which is an intermediate compound, was dissolved in dimethylformamide (DMF). (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-oxazolidin-2-one and sodium hydride were added dropwise to the obtained solution at room temperature. After the completion of the reaction, the reaction mixture was extracted with ethyl acetate, washed with water and brine, dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was separated by MPLC (Si02, 5:1 n-hexane : EtOAc), thus obtaining Compound 304 (60 mg, 46%) as white oil.1H NMR (400 MHz, DMSO-d6); atropisomer mixture; delta 7.86 (s, 1 H), 7.79 (s, 2 H), 7.36 – 7.39 (m, 1 H), 6.88 – 6.95 (m, 3 H), 5.57 – 5.62 (m, 1 H), 5.17 (d, 1 H, J= 9.9 Hz), 3.96 -4.04 (m, 2 H), 3.79 – 3.82 (2s, 3 H), 3.58 – 3.62 (m, 3 H), 3.44 – 3.58 (m, 1 H), 2.00 – 2.50 (m, 2 H), 1.93 – 1.95 (m, 2 H), 1.50 – 1.55 (m, 2 H), 1.02 – 1.07 (m, 6 H), 0.37, 0.43 (2d, 3 H, J= 6.6,6.5 Hz); MS (ESI) m/z 714 (M+ + H).
The synthetic route of 875444-08-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Seohee; OH, Jungtaek; LEE, Jaekwang; LEE, Jaewon; BAE, Suyeal; HA, Nina; LEE, Sera; WO2012/141487; (2012); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem