The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,6-Dichloropurine(SMILESS: C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2,cas:5451-40-1) is researched.Related Products of 70-23-5. The article 《HFIP Promoted Low Temperature SNAr of Chloroheteroarenes Using Thiols and Amines》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:5451-40-1).
A highly efficient and an unprecedented HFIP promoted low temperature aromatic nucleophilic substitutions of chloroheteroarenes has been performed using thiols and (secondary) amines under base-free and metal-free conditions. The developed protocol also provides excellent regio-control for the selective functionalization of dichloroheteroarenes, while the utility of the protocol was demonstrated by the modification of a com. available drug Ceritinib.
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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem