497-25-6, Oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
497-25-6, Synthesis of (1R, 2R) and (IS, 2S)-methyl-3-(2-(4-chlorophenyl)-5′-fluoro-2-isopropyl- 2′-oxospiro [cyclopropane- 1 ,3′-indoline] – 1 ‘-yl) -5- (2-oxooxazolidin-3-yl)benzoate3-bromo-5-((lS,2S)-2-(4-chlorophenyl)-5′-fiuoro-2-isopropyl-2′-oxospiro[cyclopropane- l,3′-indoline]-l’-yl)benzoate, 3-bromo-5-((lR,2R)-2-(4-chlorophenyl)-5′-fiuoro-2- isopropyl-2′-oxospiro[cyclopropane-l,3′-indoline]-l’-yl)benzoate (0.545 g, 1 mmol), 2- oxazolidone (0.105 g, 1.2 mmol), Cul (20 mg), and K2C03 (0.276 g, 2 mmol) were placed in a Schlenk tube under Argon atmosphere and dissolved in dry acetonitrile. The N, N’- dimethyl-l,2-ehtanediamine (21 L, 20%equiv) was added into the mixture. The mixture was strirred at 80 C for 14 hours. The solvent was removed in vacuo and the residue was purified by flash column chromatography to give the title compound as white powder (0.40 g, 73%). LC/MS m/e calcd. for C30H26CIFN2O5: 548, observed (M+H)+: 549.5
The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; FENG, Lichun; HE, Yun; HUANG, Mengwei; YUN, Hongying; WO2011/70039; (2011); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem