452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,452339-73-0
Sodium hydride (60% dispersion in oil 1.26 g) was added to a stirred, cooled (ice-bath) solution of (5R)-5- (2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-2-oxazolidinone (5.47 g) in dry DMF (50 ml) under nitrogen and the mixture was stirred for 15 min at 5 C. A solution of 6-bromohexyl 4- (3-IODOPHENYL) BUTYL ether (10.7 g) in DMF (30 ML) was then added dropwise over 10 min. The mixture was stirred for 2 h at ambient temperature, then poured into aqueous solution of ammonium chloride and extracted into ethyl acetate. The combined extracts were washed with water, dried (NA2SO4) and evaporated. The residue was purified on biotage (90 g cartridge) eluting with ether-hexane (3: 2) to give the title compound (9.8 g). LCMS RT= 4.20 min.
The synthetic route of 452339-73-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO WELLCOME HOUSE; WO2004/37773; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem