452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 10 Preparation of (R)-3-{6-[2-(2,6-Dichlorobenzyloxy)-ethoxy]-hexyl}-5-(2,2-di methyl-4H-benzo[1,3]dioxin-6-yl)-oxazolidin-2-one (XIII) Potassium tert-butoxide (1.0eqt) was added to a solution of Compound IX (1.0eqt) in DMF (7V) under N2 and the reaction stirred for 1 h at ambient temperature. A solution of compound XII (1.0eqt) in anhydrous DMF (1.5V) was added to the above reaction mass and the reaction allowed stirring at ambient temperature for 3 hr. The reaction mixture was diluted with ice/water and extracted with ethyl acetate. The organic layer was separated then washed successively with water/saturated brine and dried over sodium sulfate. The solution was concentrated to dryness and the residue thus obtained was purified by column chromatography (EtOAc-hexane). The pure fractions were concentrated under vacuum to afford the title compound as pale yellow color oil. Yield: 91%; purity by HPLC: 99.24%; Chiral purity: R-isomer: 99.96%; S-isomer: 0.04%
The synthetic route of 452339-73-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PERRIGO API LTD.; Dammalapati, Venkata Lakshmi Narasimha Rao; Mudduluru, Hari Krishna; Aduri, Ravindra; US2015/239862; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem