Category: oxazolidine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Nickel-catalyzed cross-electrophile coupling of aryl bromides and cyclic secondary alkyl bromides with spiro-bidentate-pyox ligands. Author is Gao, Nanxing; Li, Yanshun; Cao, Guorui; Teng, Dawei.
The cross-electrophile coupling of aryl bromides RBr [R = Ph, 4-(ethoxycarbonyl)phenyl, 1-(1H-indol-1-yl)ethan-1-one, etc.] and cyclic secondary alkyl bromides I [R1 = ethoxycarbonyl, (benzyloxy)carbonyl, (4-methylbenzene)sulfonyl, etc., X = (CH2)n, n = 1, 2] catalyzed by nickel/spiro-bidentate-pyox ligands, e.g., II, with lithium chloride as the additive for the Csp2-Csp3 bond formation is reported. The reaction could tolerate functional groups such as sulfonamide, ester, aldehyde, ketone, protected indolyl, tert-butoxycarbonyl, aryl nitriles and aryl chloride. Various aryl-cyclic secondary alkyl Csp2-Csp3 bond products, e.g., III, were synthesized under optimal reaction conditions (19 examples).
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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem