So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Metelytsia, Larysa O.; Trush, Maria M.; Kovalishyn, Vasyl V.; Hodyna, Diana M.; Kachaeva, Maryna V.; Brovaret, Volodymyr S.; Pilyo, Stepan G.; Sukhoveev, Volodymyr V.; Tsyhankov, Serhii A.; Blagodatnyi, Volodymyr M.; Semenyuta, Ivan V. researched the compound: Oxazole( cas:288-42-6 ).HPLC of Formula: 288-42-6.They published the article 《1,3-Oxazole derivatives of cytisine as potential inhibitors of glutathione reductase of Candida spp.: QSAR modeling, docking analysis and experimental study of new anti-Candida agents》 about this compound( cas:288-42-6 ) in Computational Biology and Chemistry. Keywords: Candida cytisine oxazole derivative glutathione reductase mol docking; 1,3-oxazole; Candida spp.; Cytisine; Glutathione reductase; Molecular docking; QSAR. We’ll tell you more about this compound (cas:288-42-6).
Natural products as well as their derivatives play a significant role in the discovery of new biol. active compounds in the different areas of our life especially in the field of medicine. The synthesis of compounds produced from natural products including cytisine is one approach for the wider use of natural substances in the development of new drugs. QSAR modeling was used to predict and select of biol. active cytisine-containing 1,3-oxazoles. The eleven most promising compounds were identified, synthesized and tested. The activity of the synthesized compounds was evaluated using the disk diffusion method against C. albicans M 885 (ATCC 10,231) strain and clin. fluconazole-resistant Candida krusei strain. Mol. docking of the most active compounds as potential inhibitors of the Candida spp. glutathione reductase was performed using the AutoDock Vina. The built classification models demonstrated good stability, robustness and predictive power. The eleven cytisine-containing 1,3-oxazoles were synthesized and their activity against Candida spp. was evaluated. Compounds 10, 11 as potential inhibitors of the Candida spp. glutathione reductase demonstrated the high activity against C. albicans M 885 (ATCC 10,231) strain and clin. fluconazole-resistant Candida krusei strain. The studied compounds 10, 11 present the interesting scaffold for further investigation as potential inhibitors of the Candida spp. glutathione reductase with the promising antifungal properties. The developed models are publicly available online at http://ochem.eu/article/120720 and could be used by scientists for design of new more effective drugs.
If you want to learn more about this compound(Oxazole)HPLC of Formula: 288-42-6, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(288-42-6).
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem