2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Into a 8-mE vial, were placed (Z/E)-5-((6-(8-fluo- ronaphthalen-2-yl)-2-methoxypyridin-3-yl)methylene)ox- azolidine-2,4-dione (50 mg, 0.123 mmol, 1.00 equiv), CH3CN (3 ml), sodium iodide (92 mg, 0.615 mmol, 5 equiv). To the mixture was then added chiorotrimethylsilane (66 mg, 0.615 mmol, 5.00 equiv) dropwise with stirring at room temperature. The resulting solution was stirred for 2 irs at 25 C. The reaction progress was monitored by ECMS. The reaction was then quenched by the addition of MeOH (2 mE). The resulting mixture was concentrated under vacuum. The product was purified by Prep-HPEC with the following conditions (1-Waters 2767-5): Column, SunFire Prep C18, 5 um, 19* 100 mm; mobile phase, Water of 0.05% NH4HCO3 and CH3CN (28% CH3CN up to 38% in 12 mm, up to 100% in 2 mm, down to 15% in 2 mm; Detector, 254 nm to yield (E)-5-(1-(6-(8-fluoronaphthalen- 2-yl)-2-oxo- 1 ,2-dihydropyridin-3-yl)-2-methylpropylidene) oxazolidine-2,4-dione a light yellow solid10356] ?H NMR (300 MHz, CD3OD) oe: 8.44 (s, 1H), 8.06 (d, J=8.4 Hz, 1H), 7.85-7.89 (m, 1H), 7.76 (d, J=8.4 Hz, 1H),7.46-7.61 (m, 2H), 7.25-7.31 (m, 1H), 6.83 (d, J=10.8 Hz, 1H), 3.15-3.24 (m, 1H), 1.18 (brm, 6H). ?9F NMR (300 MHz, CD3OD) oe: -124.51. Mass spectrum (ESI, mlz):Calculated for C22H,7FN204, 393.1 (M+H), found 393.0. 10357] and (Z)-5-(1 -(6-(8-fluoronaphthalen-2-yl)-2-oxo-1 ,2-dihydropyridin-3-yl)-2-methylpropylidene)oxazolidine-2,4-dione as a light yellow solid. ?H NMR (300 MHz, CD3OD) oe: 8.36 (s, 1H), 7.98 (d, J=8.4 Hz, 1H), 7.78 (d, J=8.7 Hz, 1H), 7.67 (d, J=8.4 Hz, 1H), 7.41-7.49 (m, 2H), 7.16-7.23 (m, 1H), 6.74 (d, J=7.2 Hz, 1H), 4.02-4.11 (m, 1H), 1.04 (d, J=6.9 Hz, 6H). ?9F NMR (300 MHz, CD3OD) oe: -124.40. Mass spectrum (ESI, mlz): Calculated for C22H,7FN204, 393.1 (M+H), found393.0., 2346-26-1
The synthetic route of 2346-26-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Janssen Pharmaceutica NV; Zhang, Xuqing; Macielag, Mark J.; (184 pag.)US2019/47960; (2019); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem