173604-33-6, (R)-4-Benzhydryloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 6Synthesis of Side Chain with Chiral Methyl; Step 1:A 2-L, three-necked, round-bottom flask equipped with a mechanical stirrer and an argon inlet-outlet adapter connected to a bubbler was charged with a solution of (R)-(+)-4-(diphenylmethyl)-2-oxazolidinone (2, 25 g in 200 mL of THF). The solution was cooled to -78 C. under argon. To the solution was added n-butyllithium in hexanes (1.6 M, 64.80 mL) drop wise at -78 C. over a period of 45-60 minutes. The reaction mixture was stirred at -78 C. for 30-45 min. Then, propionyl chloride (20.10 g dissolved in 30-50 mL of dry THF) was added drop wise at -78 C. over 15-30 min. The mixture was stirred at -78 C. for 1-2 h (Note 1). The reaction mixture was quenched with saturated solution of ammonium chloride (15 mL) at -78 C. to -60 C. and then allowed to warm-up to ambient temperature. An additional amount of ammonium chloride (100 mL) was added to the reaction mixture at ambient temperature and the mixture was swirled in separatory funnel. The organic layer was separated from aqueous layer. The aqueous phase was extracted with MTBE (2¡Á100 mL). The combined organic phases were washed with aqueous NaHCO3 (100 mL), brine (100 mL), then dried over anhydrous Na2SO4 followed by filtration. The filtrate was concentrated in vacuo to afford crude solid product (30.38 g, quantitative)., 173604-33-6
The synthetic route of 173604-33-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Lung LLC; US2012/323025; (2012); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem