17016-83-0, (S)-4-Isopropyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution ofoxazolidine (3.9 g, 30.2 mmol) in THF (40 mL) was cooled to -63 C and treatedn-butyllithum (19 mL, 1.6 M in hexanes). After the solution was stirred at -78C for 10 min, benzyloxyacetyl chloride (3.3 g, 17.6 mmol) was added, and theresulting solution was warmed to 23 C for an hour. Reaction mixture was quenchedwith saturated aqueous NaHCO3 (60 mL) and concentrated in vacuo toremove the organic solvents. The resulting aqueous residue was extracted withEt2O (150 mL), and the combined organic layers were washed withwater (80 mL ) and brine (80 mL ), and then dried over sodium sulfate,,filtered and concentrated. Purification of the residue by flash chromatography(gradient elution, 20% to 25% EtOAc/Hexanes) ) to afforded imide 8 aswhite solid (7.1 g, 85%) mp 85.5-86.3 C; 1H NMR delta 7.32 (m, 5H), 4.69 (d, J = 1.8 Hz, 2H), 4.65 (s, 2H), 4.42 (m, 1H),4.30 (m, 1H), 4.22 (m, 1H), 2.41 (m, 1H), 0.91 (d, J = 7.2 Hz, 3H), 0.86 (d, J = 7.2 Hz, 3H); 13C NMR delta 170.1,154.0, 137.3, 73.5, 69.6, 64.5, 58.2, 28.3, 17.9, 14.7; IR (neat) 3264, 2961,1722, 1611, 1513; MS m/z: [M+H]+ Calcd for C15H19NO4;278.1; Found 278.4., 17016-83-0
The synthetic route of 17016-83-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Pal, Ashutosh; Peng, Zhenghong; Schuber Jr., Paul T.; Bhanu Prasad, Basvoju A.; Bornmann, William G.; Tetrahedron Letters; vol. 54; 41; (2013); p. 5555 – 5557;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem