160695-26-1, (R)-4-Phenyl-3-propionyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation Example 2-1: (S)-t-butyl 2-((1R,2R)-1-hydroxy-2-methyl-3-oxo-3-((R)-2-oxo-4-phenyloxazolidin-3-yl)propyl)pyrrolidine-1-carboxylate (VI-1) [0060] [0061] To a solution of (R)-4-phenyl-3-propionyloxazolidin-2-one (605 mg, 2.7 mmol) in 8 mL of dichloromethane that was cooled to 0C, triethyl amine (0.5 mL, 3.7 mmol) was added. Then, dibutylboron triflate was added dropwise and stirred drops of dibutylboron triflate were added before stirring for 45 min. The resulting solution was cooled to -78C, added dropwise of a solution of the compound (IV-1) (500 mg, 2.5 mmol), obtained in Preparation Example 1-1, in 5 mL of dichloromethane, and stirred for 1 hr. Stirring was further conducted at 0C for an additional 1 hr, and at 20?25C for an additional 1 hr. [0062] The reaction was terminated with a phosphate buffer (pH 7.2, 3 mL) and 9 mL of methanol. The reaction mixture was cooled to 0C before a mixture of methanol: 33% hydrogen peroxide (2 : 1, 9 mL) was dropwise added thereto. It was stirred for 1 hr, and concentrated in a vacuum. The concentrate was dissolved in ether, washed with saturated sodium chloride, dried over anhydrous sodium sulfate, and concentrated in a vacuum to give a yellow oil. Recrystallization in ethyl acetate afforded the title compound as a white solid. 0.59 g (59%). MS (EI) m/z : 419 [M+H]+ 1H NMR (400 MHz, CDCl3): delta 1.10 (m, 3H), 1.39 (s, 9H), 1.67?1.84 (m, 7H), 3.01 (m, 1H), 3.67?3.81 (m, 3H), 4.14 (m, 1H), 4.70 (m, 1H), 5.03 (m, 1H), 5.43 (m, 1H), 7.26?7.41 (m, 5H)
160695-26-1, The synthetic route of 160695-26-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Celltrion, Inc.; PARK, Young Jun; JEONG, Jin-kyo; CHOI, Young Mi; LEE, Min Seob; CHOI, Joon hun; CHO, Eun Joo; SONG, Hyunnam; PARK, Sung Jun; LEE, Jong-hyoup; HONG, Seung Suh; EP2889287; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem