153652-70-1, (4S,5R)-3-Benzoyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Solution OF 2-CHLOR-4, 6-DIPHENOXY-1, 3,5-triazine (CDPHT) (0. 3 g, 1 mmole) in 5 mi THF was mixed with N-methylmorpholine (0.11 ml, 1 mmole) for 30 minutes at temperature of 0-5C to obtain N- (4, 6- DIPHENOXY-1, 3, 5-triazine-2-yl)-N- methylmorpholine chloride. Then, phenyl isoserine derivative with the formula 4b, where R3= R4=CH3 (0.325 g, 1 mmol) was added and mixed for 12 hours. After N-METHYLMORPHOLINE HYDOCHLORIDE was filtered off, and solvent was evaporated it gave respective triazine ester of the formula 6b, where R3= R4=CH3, and R5=R6= OCEHG, with the quantitative yield. TLC: eluent CHCI3, RR0. 65 1H-NMR (CDCI3) : 6=1. 76 (s, 3H); 1.79 (s, 3H) ; 5.19 (d, J=8.0 Hz, 1H); 5.27 (d, J= 8. 0 Hz, 1H) ; 7.19-7. 22 (m, 2H); 7.40-7. 74 (m, 18 H) ppm] JR (KBr): 1780 [CM~1] The triazine ester, in the presence of magnesium bromide and PYROLIDINPYRIDINE, was coupled with protected Baccatin III of the generalized formula 3, where R2=Si (C2H5) 3. The product was chromatographically and SPECTRALLY identical to that described in the 11. Example.
153652-70-1, The synthetic route of 153652-70-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AGROPHARM S.A.; WO2004/56790; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem