147959-19-1, (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 1 2-FR (1R, 3S)-3-AMINO-4-HYDRY-L- (5-THIAZOLVL)YLLTHIOL-5-CHLORO-3-PYRIDINECARBONITRILE ethanedioate a) (45)-4-R (2R)-2-HVDROXV-2-(2-CHLORO-5-THIAZOLVL) ETHVLL-2*2-DIMETHYL-3- oxazolidinecarboxvlic acid, 1, 1-dimethylethyl ester and (4S)-4-[ (2S)-2-HYDROXY-2- (2- CHLORO-5-THIAZOLYL) ETHYL1-2. 2-dimethyl-3-oxazolidinecarboxylic acid, 1, 1-DIMETHYLETHYL ester n-Butyl lithium (2. 0M in hexanes, 21.6 ml) was added dropwise to a solution of 2-chlorothiazole (5.4 g) in THF (400 ML) at-78 C under a nitrogen atmosphere. After 15 minutes a solution of (4S)-2, 2-dimethyl-4- (2-oxoethyl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester (7.0 g) in THF (140 ml) was added dropwise and the reaction mixture was stirred for a further 60 minutes. The cooling was then removed and the mixture was stirred at room temperature for 60 minutes. The reaction mixture was poured into saturated aqueous ammonium chloride and the products extracted with diethyl ether. The combined extracts were washed with brine, dried (magnesium sulfate), filtered and evaporated. Purification by chromatography (silica, 20% ethyl acetate/isohexane as eluent) gave the (4S, 2S) sub-title compound (5.2 g) as a colourless oil. MS APCI +ve m/z 363 [(M+H]). LH NMR 400MHZ (DMSO-D6, 90C) 7.49 (1H, s), 5.69 (1H, d), 4.85 (1H, dd), 3.96-3. 86 (2H, m), 3.84-3. 77 (1H, m), 2.10-1. 99 (IH, m), 1.90 (1H, dt), 1.47 (3H, s), 1.40 (12H, s). Further elution gave the (4S, 2R) sub-title compound (5.1 G, 42%) as a colourless oil. MS APCI +ve m/z 363 ([M+H]). ‘H NMR 400MHZ (DMSO-D6, 90C) 7.49 (1H, s), 5.70 (1H, d), 4.92 (1H, apparent quin.), 4.05-3. 98 (IH, m), 3.91-3. 84 (2H, m), 2.16-2. 07 (1H, m), 1. 84 (1H, ddd), 1.48 (3H, s), 1.41 (12H, s)., 147959-19-1
The synthetic route of 147959-19-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; WO2004/41794; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem