147959-19-1, (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 3: (5)-tert-butyl 4-((S)-2-hydroxypropyl)-2,2-dimethyloxazolidine-3 -carboxylateTo a solution of (5)-tert-butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate (2.15 g,8.84 mmol) in dry THF (20 mL) at 18C was added 3M methylmagnesium bromide (4.42 ml,13.26 mmol) in a schlenk tube. The mixture was stirred for 16 h. TLC showed the reaction wascomplete. The mixture was diluted with sat. NH4C1 solution (40 mL) and extracted with EtOAc (70 mL x 3). The combined organic layers were washed with water (40 mL) and brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified with combi flash (flash colunm silica-CS (40 g) PE/EtOAc= 100:1 5: 1) to give the title compound. MS (ESI) m/z 260.1 (M+H).
147959-19-1, The synthetic route of 147959-19-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIM, Yeon-Hee; GUO, Zhuyan; ALI, Amjad; EDMONDSON, Scott, D.; LIU, Weiguo; GALLO-ETIENNE, Gioconda, V.; WU, Heping; GAO, Ying-Duo; STAMFORD, Andrew, M.; YU, Younong; KEVIN, Nancy, J.; ANAND, Rajan; SHA, Deyou; NEELAMKAVIL, Santhosh, F.; HUSSAIN, Zahid; KUMAR, Puneet; MONINGKA, Remond; DUFFY, Joseph, L.; XU, Jiayi; JIANG, Yu; SONE, Hiroki; CHAKRABARTI, Anjan; (183 pag.)WO2015/164308; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem