131685-53-5, (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a tetrahydrofuran solution (12.0 mL) containing (S) -4-benzyl-3-propionyloxazolidin-2-one (a1) (1.12 g, 4.81 mmol) was added sodium bis (trimethylsilyl ) Amide in tetrahydrofuran (1.0 M, 9.6 mL, 9.61 mmol) was added dropwise. After stirring the reaction mixture at -78 C. for 15 minutes, a solution of (2E, 4E) -1-bromohexa-2,4-diene (b1) (1.55 g, 9.61 mmol) and tetrabutylammonium iodide (177 mg, 0.481 mmol) was added, the temperature was raised to room temperature, and the mixture was stirred for 1 hour. Saturated ammonium chloride aqueous solution was added to the reaction system at 0 C. to stop the reaction, ethyl acetate was added and the organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain a crude product. The resulting crude product was purified by column chromatography to give (S) -3 – ((R, 4E, 6E) -2-methylocta-4,6-dienoyl) -4- benzyloxazolidin- (1.31 g, 87%).
131685-53-5, The synthetic route of 131685-53-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TOKYO UNIVERSITY OF SCIENCE FOUNDATION; JAPANESE FOUNDATION FOR CANCER RESEARCH; SHIINA, ISAMU; YAMORI, TAKAO; (60 pag.)JP6143266; (2017); B2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem