On September 7, 2007, Beddow, James E.; Davies, Stephen G.; Ling, Kenneth B.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E. published an article.SDS of cas: 168297-86-7 The title of the article was Asymmetric synthesis of β2-amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives. And the article contained the following:
Conjugate addition of lithium dibenzylamide to the SuperQuat derivative (S)-3-acryloyl-4-isopropyl-5,5-dimethyloxazolidin-2-one (derived from L-valine) and alkylation of the resultant lithium β-amino enolate provide, after deprotection, a range of (S)-2-alkyl-3-aminopropanoic acids in good yields and high enantiomeric excesses. Alternatively, conjugate addition of a range of secondary lithium amides to (S)-3-(2-alkylacryloyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one SuperQuat derivatives, diastereoselective protonation with 2-pyridone, and subsequent deprotection furnish a range of (R)-2-alkyl- and (R)-2-aryl-3-aminopropanoic acids in good yields and high enantiomeric excesses. Addnl., the boron-mediated aldol reaction of β-amino N-acyloxazolidinones is a highly diastereoselective method for the synthesis of a range of β-amino-β’-hydroxy N-acyloxazolidinones. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).SDS of cas: 168297-86-7
The Article related to alkylaminopropanoic acid preparation conjugate addition alkylation, superquat derivative conjugate addition alkylation, oxazolidinone amino hydroxy acyl preparation, asym synthesis beta amino acid and other aspects.SDS of cas: 168297-86-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem