One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of (S)-5-(Chloromethyl)oxazolidin-2-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one, molecular formula is C4H6ClNO2
Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5- triazines as novel Hsp90 inhibitors
A novel series of 2-amino-1,3,5-triazines bearing a tricyclic moiety as heat shock protein 90 (Hsp90) inhibitors is described. Molecular design was performed using X-ray cocrystal structures of the lead compound CH5015765 and natural Hsp90 inhibitor geldanamycin with Hsp90. We optimized affinity to Hsp90, in vitro cell growth inhibitory activity, water solubility, and liver microsomal stability of inhibitors and identified CH5138303. This compound showed high binding affinity for N-terminal Hsp90alpha (Kd = 0.52 nM) and strong in vitro cell growth inhibition against human cancer cell lines (HCT116 IC50 = 0.098 muM, NCI-N87 IC50 = 0.066 muM) and also displayed high oral bioavailability in mice (F = 44.0%) and potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model (tumor growth inhibition = 136%).
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Quality Control of (S)-5-(Chloromethyl)oxazolidin-2-one, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 169048-83-3
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1403NO – PubChem