Synthetic Route of 169048-83-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one,introducing its new discovery.
Electrochemical oxidation of chiral 5-substituted 2-oxazolidinones: A key building block for dichiral beta-amino alcohols
The 4-methoxylation of some chiral 5-substituted 2-oxazolidinones can be performed successfully by direct electrochemical oxidation el 50 mA/cm2 in methanol at graphite electrodes using an undivided or quasi-divided cell and sodium tetrafluoroborate or sodium benzene sulfonate as supporting electrolytes. The yields and selectivities are depending on the pH of the solution and the concentration of the substrate. Thus, (4RS,5S)- chloromethyl-4-methoxy-2-oxazolidinone (7) could be obtained in 76% yield from (5S)-chloromethyl-2-oxazolidinone (3). Through nucleophilic methoxy- group exchange these heterocycles are key intermediates for enantiomerically pure trans-4,5-difunctionalized-2-oxazolidinones in both enantiomeric forms, which are very interesting targets due to their various pharmacological effects and as precursors for beta-amino alcohols and protease inhibitors.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 169048-83-3, and how the biochemistry of the body works.Synthetic Route of 169048-83-3
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1394NO – PubChem