Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Efficient synthesis of new oxadiazole-thiazole hybrids using (diacetoxyiodo)benzene.COA of Formula: C5H7BrO3.
An efficient synthesis of some new 2-aryl-5-(2′-(4-nitrophenylamino)thiazol-4′-yl)-1,3,4-oxadiazoles I (R = H, Cl, Br, F, Me), has been accomplished through oxidative cyclization of 2-(4-nitrophenylamino)-N’-(substituted benzylidene)thiazole-4-carbohydrazides II using an ecofriendly oxidant, (diacetoxyiodo)benzene at ambient temperature The reaction can tolerate a wide range of aldehydes 4-RC6H4CHO to afford the corresponding unsym. 2,5-disubstituted 1,3,4-oxadiazoles I. The mild reaction conditions, relatively benign nonmetallic oxidant and short reaction time are noteworthy advantages of this methodol.
As far as I know, this compound(70-23-5)COA of Formula: C5H7BrO3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem