Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: oxazolidine. Introducing a new discovery about 184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one
Asymmetric zinc-Reformatsky reaction of Evans chiral imide with acetophenones and its application to the stereoselective synthesis of triazole antifungal agents
The Ni(acac)2 catalytic ZnEt2-mediated asymmetric Reformatsky-type reaction of Evans chiral imide with various acetophenones was studied. The chiral imido zinc enolate, which was formed through the metal-halogen exchange reaction of chiral alpha-bromopropionyl-2-oxazolidinones 2 with diethyl zinc under the catalysis of Ni(acac)2, performed the asymmetric zinc-Reformatsky reaction with activated alpha-haloacetophenones 3 to give the chiral beta-hydroxyamide 4 in good yields and high ratios of syn-(2R,3R)-isomers (up to >97%). This new asymmetric synthesis technology affords a practical method to synthesize the versatile chiral building block 5 for triazole antifungal agents, such as Voriconazole, Ravuconazole, TAK-187, and RO-0094815.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: oxazolidine, you can also check out more blogs about184346-45-0
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Oxazolidine – Wikipedia,
Oxazolidine | C3H2654NO – PubChem