Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 99395-88-7, 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, SMILES is [C@H]1(NC(OC1)=O)C2=CC=CC=C2, belongs to oxazolidines compound. In a document, author is Nogueira, Thais C. M., introduce the new discover.
A New Synthesis of Chiral Oxazolidinones from the Amino Acid L-serine
Cyclization of the (4S)-PhCH2OCONHCH(CH2OH) CONHN=CH-aryl, obtained in 4 steps from L-serine, on treatment with MeI and potassium carbonate, generates the chiral oxazolidinones, (4S)-N’-[(E)-(phenyl) methylidene]-N-methyl-2-oxo-1,3-oxazolidine-4-carbohydrazides. Overall the formation of the (4S)-N’-[(E)-(phenyl) methylidene]-Nmethyl-2-oxo-1,3-oxazolidine-4-carbohydrazides from L-serine occurs with retention of configuration, as confirmed by Xray crystallography. In contrast, the reaction of the N-Boc analogues, (4S)-t-BuOCONHCH(CH2OH) CONHN=CH-aryl, on treatment with MeI / K2CO3, simply leads to N-methylation without cyclization and without loss of the Boc protecting group to give (4S)-t-BuOCONMeCH(CH2OH) CONHN=CH-aryl. The difference between the Boc and Cbz derivatives is striking and is probably linked to the greater bulk of the Boc group blocking the intramolecular acyl transfer.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 99395-88-7 is helpful to your research. Recommanded Product: 99395-88-7.
Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem