Synthetic Route of 497-25-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a article£¬once mentioned of 497-25-6
One pot microwave-assisted synthesis of 3-benzyl-5-hydroxymethyl-1, 3-oxazolidin-2-one
Oxazolidinone is a five-member heterocyclic ring used as a privileged structure for the synthesis of ligands for different biological targets. Many synthetic approaches have been made available for oxazolidinone, however, they were found to be either time/energy consuming or multistep process. One of the approach is a one-pot method to synthesize 3-benzyl-5-hydroxymethyl-oxazolidin-2-one using reflux overnight (>12 h). The aim of the present work was to develop an improved method by the use of microwave irradiation to make 3-benzyl-5-hydroxymethyl-oxazolidin-2-one. Benzyl amine was reacted with the various carbonate salts and epichlorohydrin, in presence of bases and solvent and the reaction was carried out under open and sealed-vessel conditions. Various factors including the use of carbonate salts, base, solvent, time, temperature and power were optimized. Microwave-assisted synthesis of 3-benzyl-5-hydroxymethyl-1,3-oxazolidin-2-one gave yields of 69.59% and 77.0% in an open vessel and a closed vessel, respectively with reduction in reaction time from overnight (>12 h) to 1 h in the open vessel and to 30 min in closed vessel.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 497-25-6
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H884NO – PubChem