In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called 9-Sulfonyl-9(H)-Purine Derivatives Inhibit HCV Replication Via their Degradation Species, published in 2021-04-30, which mentions a compound: 5451-40-1, mainly applied to sulfonylpurine degradation species hepatitis C virus inhibitor, Application In Synthesis of 2,6-Dichloropurine.
Cell-based screening of a privileged small mol. library led to the discovery of 9-sulfonyl-9(H)-purine as new scaffold for hepatitis C virus (HCV) inhibitors. Structure-activity relationship study with respect to the 2-, 6- and 9-positions in the purine core resulted in the identification of several active compounds with moderate potency against the HCV genotype 1b. Subsequent stability studies demonstrated that HCV inhibitors of this type were unstable in Dulbecco’s modified eagle medium (DMEM) and plasma, as well as glutathione-containing water, and their instability was closely related to their HCV inhibitory activity. A preliminary study of the mechanism of action showed that the sulfonamide bond at the 9-position of purine would be the primary degradation site and the resulting sulfonylation degradation species would mediate the anti-HCV activity of 9-sulfonyl-9(H)-purines. Results of this study demonstrated that 9-sulfonyl-9(H)-purine is an unstable scaffold for HCV inhibitors and further detailed anal. of the degradation species is needed to determine the main active components and direct target for this type of mols.
This literature about this compound(5451-40-1)Application In Synthesis of 2,6-Dichloropurinehas given us a lot of inspiration, and I hope that the research on this compound(2,6-Dichloropurine) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem