With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
S-(+)-4-PHENYL-OXAZOLIDIN-2-ONE (2.81 g, 17.2 MMOL), 4-bromo-N-propyl- benzamide (4.17 g, 17.2 MMOL), CUL (0.32 g, 1.72 MMOL) and potassium carbonate (4.76 g, 17.2 MMOL) were charged to a nitrogen-purged flask. The flask was evacuated and backfilled with nitrogen before addition of dioxane (17.2 ml). To the above reaction mixture, 1, 2-diaminocyclohexane (0.21 ML, 1.72 MMOL) was added via syringe. The resulting bright blue mixture was heated at 110C FOR 15.5 hours. Analysis (HPLC/MS) of the reaction mixture indicated that the reaction was complete. The oil bath was cooled to 45C, and any precipitated product was dissolved by the addition of DICHLOROMETHANE (50 ml). The mixture was filtered through celite and the solids were washed with an additional 50 ml of warm dichloromethane. The combined filtrates were concentrated and vacuum dried to give the desired OXAZOLIDINE as a light brown solid in near quantitative yield (5.6 g). Mass spec: 325 (m +1). ‘H NMR (CDC13) 8 0.94 (t, J =7.5, 3H), 1.59 (m, 2H), 3.35 (m, 2H), 4.21 (m, 1 H), 4.80 (m, 1H), 5.43 (m, 1H), 6.16 (br, 1H), 7.27 (d, J=7.9, 2H), 7.34 (m, 3H), 7.46 (d, J =8.0, 2H), 7.64 (d, J =8.3, 2H). 3C NMR (CDC13) 8 11.66, 23. 08, 41.96, 60.54, 70.10, 120.10, 126,127. 95, 129.24, 129.75, 130.77, 137.96, 139.81, 155.84, 167. 02., 99395-88-7
The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER PRODUCTS INC.; WO2004/39785; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem