With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
The compound of formula II (250 g, 1.53 mol) was added to toluene (3750 mL)Heat to 70 degrees. Sodium methoxide methanol solution (29 wt%, 314 g, 1.68 mol) was added dropwise.Plus End, atmospheric distillation of methanol. Cooled to 0-5 C,The compound of formula III (364.4 g, 1.68 mol)Temperature is not higher than 20 . Add finished, the reaction 1-2 hours.After the reaction was completed, water (250 mL) was added, heated to 50-60 C, allowed to stand for delamination and the aqueous phase was separated.The organic phase is washed twice with water. The organic phase was concentrated to give the crude product.The crude product was beaten with n-hexane (1500 mL), filtered and dried to obtain the intermediate of formula IV.Yield: 436g, yield: 95.4%
The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; (11 pag.)CN107573304; (2018); A;,
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