With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90719-32-7,(S)-4-Benzyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
90719-32-7, Add 1000ml of dichloromethane to a 5-liter four-neck bottle.Triethylamine 500ml (3.6mol), benzyl oxazolidinone 177g(1 mol), 80 g (1.1 mol) of propionic acid,Add 300g (1mol)a solution of methyl 2-chloropyridine p-toluenesulfonate in 1000 ml of dichloromethane,After the addition, stirring at 20 C for 7 hours, TLC showed the reaction was complete, and the reaction was added with water.The organic phase was washed with water and brine, dried over anhydrous sodiumRecrystallization gave 220 g of product with a yield of 94.4% and HPLC purity >99%.
The synthetic route of 90719-32-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai Lark Pharmaceutical Technology Co., Ltd.; Shen Xin; Yang Jidong; Hu Xiaochuan; Li Feng; (6 pag.)CN109020914; (2018); A;,
Oxazolidine – Wikipedia
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